Synthesis of water-soluble paclitaxel derivatives by enzymatic acylation

被引:83
作者
Khmelnitsky, YL
Budde, C
Arnold, JM
Usyatinsky, A
Clark, DS
Dordick, JS
机构
[1] UNIV CALIF BERKELEY,DEPT CHEM ENGN,BERKELEY,CA 94720
[2] ENZYMED INC,IOWA CITY,IA 52242
[3] UNIV IOWA,DEPT CHEM & BIOCHEM ENGN,IOWA CITY,IA 52242
关键词
D O I
10.1021/ja973103z
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
引用
收藏
页码:11554 / 11555
页数:2
相关论文
共 26 条
[1]   H-1-NMR AND C-13-NMR ASSIGNMENTS FOR TAXOL, 7-EPI-TAXOL, AND CEPHALOMANNINE [J].
CHMURNY, GN ;
HILTON, BD ;
BROBST, S ;
LOOK, SA ;
WITHERUP, KM ;
BEUTLER, JA .
JOURNAL OF NATURAL PRODUCTS, 1992, 55 (04) :414-423
[2]   SYNTHESIS OF CONGENERS AND PRODRUGS .3. WATER-SOLUBLE PRODRUGS OF TAXOL WITH POTENT ANTITUMOR-ACTIVITY [J].
DEUTSCH, HM ;
GLINSKI, JA ;
HERNANDEZ, M ;
HAUGWITZ, RD ;
NARAYANAN, VL ;
SUFFNESS, M ;
ZALKOW, LH .
JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (04) :788-792
[3]  
DORDICK JS, 1991, APPLIED BIOCATALYSIS, V1, P1
[4]  
HANSON RL, 1994, J BIOL CHEM, V269, P22145
[5]   SALTS DRAMATICALLY ENHANCE ACTIVITY OF ENZYMES SUSPENDED IN ORGANIC-SOLVENTS [J].
KHMELNITSKY, YL ;
WELCH, SH ;
CLARK, DS ;
DORDICK, JS .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (06) :2647-2648
[6]   ENGINEERING BIOCATALYTIC SYSTEMS IN ORGANIC MEDIA WITH LOW WATER-CONTENT [J].
KHMELNITSKY, YL ;
LEVASHOV, AV ;
KLYACHKO, NL ;
MARTINEK, K .
ENZYME AND MICROBIAL TECHNOLOGY, 1988, 10 (12) :710-724
[7]   THE CHEMISTRY OF TAXOL, A CLINICALLY USEFUL ANTICANCER AGENT [J].
KINGSTON, DGI ;
SAMARANAYAKE, G ;
IVEY, CA .
JOURNAL OF NATURAL PRODUCTS, 1990, 53 (01) :1-12
[8]   TAXOL - THE CHEMISTRY AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF A NOVEL ANTICANCER AGENT [J].
KINGSTON, DGI .
TRENDS IN BIOTECHNOLOGY, 1994, 12 (06) :222-227
[9]   THE CHEMISTRY OF TAXOL [J].
KINGSTON, DGI .
PHARMACOLOGY & THERAPEUTICS, 1991, 52 (01) :1-34
[10]   ASYMMETRIC TRANSFORMATIONS CATALYZED BY ENZYMES IN ORGANIC-SOLVENTS [J].
KLIBANOV, AM .
ACCOUNTS OF CHEMICAL RESEARCH, 1990, 23 (04) :114-120