Thrombin Generation in Chronic Liver Diseases-A Pilot Study

被引：2

作者：

Vecerzan, Liliana ^{[1
]}

Olteanu, Ariela ^{[2
]}

Maniu, Ionela ^{[3
]}

Boicean, Adrian ^{[1
]}

Cipaian, Calin Remus ^{[1
]}

Dura, Horatiu ^{[1
]}

Fleca, Sorin Radu ^{[1
]}

Mihaila, Romeo Gabriel ^{[1
]}

机构：

[1] Romania Lucian Blaga Univ Sibiu, Fac Med, Sibiu 550024, Romania

[2] Emergency Cty Clin Hosp Sibiu, Clin Lab, Sibiu 550245, Romania

[3] Lucian Blaga Univ Sibiu, Fac Sci, Res Ctr Informat & Informat Technol, Math & Informat Dept, Sibiu 550024, Romania

来源：

HEALTHCARE | 2021年 / 9卷 / 05期

关键词：

coagulation; chronic hepatitis; liver cirrhosis; thrombin generation; CIRRHOSIS;

D O I：

10.3390/healthcare9050550

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

The knowledge about coagulation disorders in patients with chronic liver disease changed in the last decade. The aim of this study was to analyze the parameters of thrombin generation in patients with chronic liver disease, as they are the most appropriate biomarkers to explore coagulation. (1) Background: The knowledge about coagulation disorders in patients with chronic liver disease changed in the last decade. The study of thrombin generation in patients with chronic liver disease provides a much more accurate assessment of the coagulation cascade; (2) Methods: This study is a prospective observational pilot study on hospitalized patients with chronic liver diseases that analyzed thrombin generation performed from their platelet-poor plasma versus that of control subjects. We analyzed a group of 59 patients with chronic liver disease and 62 control subjects; (3) Results: Thrombin generation was lower in hepatitis and cirrhosis patients compared to controls and decreases as the disease progressed. Lag time was higher in ethanolic etiology compared to the control group. Peak thrombin and endogenous thrombin potential were shorter in all etiologies when compared to the control group. The velocity index was significantly lower in HCV hepatopathies, ethanolic, and mixed etiology when compared with normal individuals; (4) Conclusions: Given the variability of thrombin generation in patients with chronic liver disease, its assay could serve to identify patients with high thrombotic and hemorrhagic risk and establish personalized conduct toward them.

引用

页数：9

共 24 条

[1]

Andronescu Craita Isabela, 2018, J Med Life, V11, P20

[2] Number of hospital contacts with alcohol problems predicts later risk of alcoholic liver cirrhosis [J].