共 105 条
Scaling of immune responses against intracellular bacterial infection
被引:34
作者:

Abdullah, Zeinab
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Bonn, Inst Mol Med, Bonn, Germany
Univ Bonn, Inst Expt Immunol, Bonn, Germany Univ Bonn, Inst Mol Med, Bonn, Germany

Knolle, Percy A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Bonn, Inst Mol Med, Bonn, Germany
Univ Bonn, Inst Expt Immunol, Bonn, Germany
Tech Univ Munich, Inst Mol Immunol, D-80290 Munich, Germany Univ Bonn, Inst Mol Med, Bonn, Germany
机构:
[1] Univ Bonn, Inst Mol Med, Bonn, Germany
[2] Univ Bonn, Inst Expt Immunol, Bonn, Germany
[3] Tech Univ Munich, Inst Mol Immunol, D-80290 Munich, Germany
关键词:
cytosolic pattern recognition receptors;
interferon;
RIG-I inflammasome activation;
secreted bacterial nucleic acids;
TOLL-LIKE RECEPTORS;
CD8(+) T-CELLS;
NF-KAPPA-B;
LISTERIA-MONOCYTOGENES INFECTION;
PATTERN-RECOGNITION RECEPTORS;
I INTERFERON;
INFLAMMASOME ACTIVATION;
INNATE IMMUNITY;
KUPFFER CELLS;
NITRIC-OXIDE;
D O I:
10.15252/embj.201489055
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Macrophages detect bacterial infection through pattern recognition receptors (PRRs) localized at the cell surface, in intracellular vesicles or in the cytosol. Discrimination of viable and virulent bacteria from non-virulent bacteria (dead or viable) is necessary to appropriately scale the anti-bacterial immune response. Such scaling of anti-bacterial immunity is necessary to control the infection, but also to avoid immunopathology or bacterial persistence. PRR-mediated detection of bacterial constituents in the cytosol rather than at the cell surface along with cytosolic recognition of secreted bacterial nucleic acids indicates viability and virulence of infecting bacteria. The effector responses triggered by activation of cytosolic PRRs, in particular the RIG-I-induced simultaneous rapid type I IFN induction and inflammasome activation, are crucial for timely control of bacterial infection by innate and adaptive immunity. The knowledge on the PRRs and the effector responses relevant for control of infection with intracellular bacteria will help to develop strategies to overcome chronic infection.
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收藏
页码:2283 / 2294
页数:12
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共 105 条
- [1] RIG-I detects infection with live Listeria by sensing secreted bacterial nucleic acids[J]. EMBO JOURNAL, 2012, 31 (21) : 4153 - 4164Abdullah, Zeinab论文数: 0 引用数: 0 h-index: 0机构: Univ Bonn, Inst Mol Med, Bonn, Germany Univ Bonn, Inst Expt Immunol, Bonn, Germany Univ Bonn, Inst Mol Med, Bonn, GermanySchlee, Martin论文数: 0 引用数: 0 h-index: 0机构: Univ Bonn, Inst Clin Chem & Clin Pharmacol, Bonn, Germany Univ Bonn, Inst Mol Med, Bonn, GermanyRoth, Susanne论文数: 0 引用数: 0 h-index: 0机构: Tech Univ Munich, Klinikum Rechts Isar, Inst Klin Chem & Pathobiochem, D-8000 Munich, Germany Univ Bonn, Inst Mol Med, Bonn, GermanyAbu Mraheil, Mobarak论文数: 0 引用数: 0 h-index: 0机构: Univ Giessen, Inst Med Microbiol, Giessen, Germany Univ Bonn, Inst Mol Med, Bonn, GermanyBarchet, Winfried论文数: 0 引用数: 0 h-index: 0机构: Univ Bonn, Inst Clin Chem & Clin Pharmacol, Bonn, Germany Univ Bonn, Inst Mol Med, Bonn, GermanyBoettcher, Jan论文数: 0 引用数: 0 h-index: 0机构: Univ Bonn, Inst Mol Med, Bonn, Germany Univ Bonn, Inst Expt Immunol, Bonn, Germany Univ Bonn, Inst Mol Med, Bonn, GermanyHain, Torsten论文数: 0 引用数: 0 h-index: 0机构: Univ Giessen, Inst Med Microbiol, Giessen, Germany Univ Bonn, Inst Mol Med, Bonn, GermanyGeiger, Sergej论文数: 0 引用数: 0 h-index: 0机构: Univ Bonn, Inst Mol Med, Bonn, Germany Univ Bonn, Inst Expt Immunol, Bonn, Germany Univ Bonn, Inst Mol Med, Bonn, GermanyHayakawa, Yoshihiro论文数: 0 引用数: 0 h-index: 0机构: Aichi Inst Technol, Dept Appl Chem, Aichi, Japan Univ Bonn, Inst Mol Med, Bonn, GermanyFritz, Joerg H.论文数: 0 引用数: 0 h-index: 0机构: McGill Univ, Dept Microbiol & Immunol, Montreal, PQ, Canada Univ Bonn, Inst Mol Med, Bonn, GermanyCivril, Filiz论文数: 0 引用数: 0 h-index: 0机构: Univ Munich, Dept Biochem, Gene Ctr, Munich, Germany Univ Bonn, Inst Mol Med, Bonn, GermanyHopfner, Karl-Peter论文数: 0 引用数: 0 h-index: 0机构: Univ Munich, Dept Biochem, Gene Ctr, Munich, Germany Univ Bonn, Inst Mol Med, Bonn, GermanyKurts, Christian论文数: 0 引用数: 0 h-index: 0机构: Univ Bonn, Inst Mol Med, Bonn, Germany Univ Bonn, Inst Expt Immunol, Bonn, Germany Univ Bonn, Inst Mol Med, Bonn, GermanyRuland, Juergen论文数: 0 引用数: 0 h-index: 0机构: Tech Univ Munich, Klinikum Rechts Isar, Inst Klin Chem & Pathobiochem, D-8000 Munich, Germany Helmholtz Zentrum Munchen, Lab Signaling Immune Syst, Neuherberg, Germany Univ Bonn, Inst Mol Med, Bonn, GermanyHartmann, Gunther论文数: 0 引用数: 0 h-index: 0机构: Univ Bonn, Inst Clin Chem & Clin Pharmacol, Bonn, Germany Univ Bonn, Inst Mol Med, Bonn, GermanyChakraborty, Trinad论文数: 0 引用数: 0 h-index: 0机构: Univ Giessen, Inst Med Microbiol, Giessen, Germany Univ Bonn, Inst Mol Med, Bonn, GermanyKnolle, Percy A.论文数: 0 引用数: 0 h-index: 0机构: Univ Bonn, Inst Mol Med, Bonn, Germany Univ Bonn, Inst Expt Immunol, Bonn, Germany Univ Bonn, Inst Mol Med, Bonn, Germany
- [2] RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate[J]. NATURE IMMUNOLOGY, 2009, 10 (10) : 1065 - U40Ablasser, Andrea论文数: 0 引用数: 0 h-index: 0机构: Univ Bonn, Inst Clin Chem & Pharmacol, D-5300 Bonn, Germany Univ Bonn, Inst Clin Chem & Pharmacol, D-5300 Bonn, GermanyBauernfeind, Franz论文数: 0 引用数: 0 h-index: 0机构: Univ Bonn, Inst Clin Chem & Pharmacol, D-5300 Bonn, Germany Univ Bonn, Inst Clin Chem & Pharmacol, D-5300 Bonn, GermanyHartmann, Gunther论文数: 0 引用数: 0 h-index: 0机构: Univ Bonn, Inst Clin Chem & Pharmacol, D-5300 Bonn, Germany Univ Bonn, Inst Clin Chem & Pharmacol, D-5300 Bonn, Germany论文数: 引用数: h-index:机构:Fitzgerald, Katherine A.论文数: 0 引用数: 0 h-index: 0机构: Univ Massachusetts, Sch Med, Div Infect Dis & Immunol, Worcester, MA USA Univ Bonn, Inst Clin Chem & Pharmacol, D-5300 Bonn, GermanyHornung, Veit论文数: 0 引用数: 0 h-index: 0机构: Univ Bonn, Inst Clin Chem & Pharmacol, D-5300 Bonn, Germany Univ Bonn, Inst Clin Chem & Pharmacol, D-5300 Bonn, Germany
- [3] Pathogen recognition and innate immunity[J]. CELL, 2006, 124 (04) : 783 - 801Akira, S论文数: 0 引用数: 0 h-index: 0机构: Osaka Univ, Res Inst Microbial Dis, Dept Host Defense, Suita, Osaka 5650871, JapanUematsu, S论文数: 0 引用数: 0 h-index: 0机构: Osaka Univ, Res Inst Microbial Dis, Dept Host Defense, Suita, Osaka 5650871, JapanTakeuchi, O论文数: 0 引用数: 0 h-index: 0机构: Osaka Univ, Res Inst Microbial Dis, Dept Host Defense, Suita, Osaka 5650871, Japan
- [4] Toll-like receptor signalling[J]. NATURE REVIEWS IMMUNOLOGY, 2004, 4 (07) : 499 - 511Akira, S论文数: 0 引用数: 0 h-index: 0机构: Osaka Univ, Dept Host Def, Microbial Dis Res Inst, Osaka 5650871, Japan论文数: 引用数: h-index:机构:
- [5] Anthrax Toxin Induces Macrophage Death by p38 MAPK Inhibition but Leads to Inflammasome Activation via ATP Leakage[J]. IMMUNITY, 2011, 35 (01) : 34 - 44Ali, Syed Raza论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Dept Pharmacol, Lab Signal Transduct, La Jolla, CA 92093 USA Univ Calif San Diego, Dept Pathol, La Jolla, CA 92093 USA Univ Calif San Diego, Dept Pharmacol, Lab Signal Transduct, La Jolla, CA 92093 USATimmer, Anjuli M.论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Dept Pediat, La Jolla, CA 92093 USA Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA Univ Calif San Diego, Dept Pharmacol, Lab Signal Transduct, La Jolla, CA 92093 USABilgrami, Sameera论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Dept Pathol, La Jolla, CA 92093 USA Univ Calif San Diego, Dept Pharmacol, Lab Signal Transduct, La Jolla, CA 92093 USAPark, Eek Joong论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Dept Pharmacol, Lab Signal Transduct, La Jolla, CA 92093 USA Univ Calif San Diego, Dept Pathol, La Jolla, CA 92093 USA Univ Calif San Diego, Dept Pharmacol, Lab Signal Transduct, La Jolla, CA 92093 USAEckmann, Lars论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA Univ Calif San Diego, Dept Pharmacol, Lab Signal Transduct, La Jolla, CA 92093 USANizet, Victor论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Dept Pediat, La Jolla, CA 92093 USA Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA Univ Calif San Diego, Dept Pharmacol, Lab Signal Transduct, La Jolla, CA 92093 USAKarin, Michael论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Dept Pharmacol, Lab Signal Transduct, La Jolla, CA 92093 USA Univ Calif San Diego, Dept Pathol, La Jolla, CA 92093 USA Univ Calif San Diego, Dept Pharmacol, Lab Signal Transduct, La Jolla, CA 92093 USA
- [6] Evasion of Toll-like receptor 5 by flagellated bacteria[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (26) : 9247 - 9252Andersen-Nissen, E论文数: 0 引用数: 0 h-index: 0机构: Inst Syst Biol, Seattle, WA 98103 USASmith, KD论文数: 0 引用数: 0 h-index: 0机构: Inst Syst Biol, Seattle, WA 98103 USAStrobe, KL论文数: 0 引用数: 0 h-index: 0机构: Inst Syst Biol, Seattle, WA 98103 USABarrett, SLR论文数: 0 引用数: 0 h-index: 0机构: Inst Syst Biol, Seattle, WA 98103 USACookson, BT论文数: 0 引用数: 0 h-index: 0机构: Inst Syst Biol, Seattle, WA 98103 USALogan, SM论文数: 0 引用数: 0 h-index: 0机构: Inst Syst Biol, Seattle, WA 98103 USAAderem, A论文数: 0 引用数: 0 h-index: 0机构: Inst Syst Biol, Seattle, WA 98103 USA
- [7] STING-Dependent Type I IFN Production Inhibits CellMediated Immunity to Listeria monocytogenes[J]. PLOS PATHOGENS, 2014, 10 (01)Archer, Kristina A.论文数: 0 引用数: 0 h-index: 0机构: Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USADurack, Juliana论文数: 0 引用数: 0 h-index: 0机构: Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USAPortnoy, Daniel A.论文数: 0 引用数: 0 h-index: 0机构: Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA
- [8] The impact of Toll-like receptors on bacterial virulence strategies[J]. CURRENT OPINION IN MICROBIOLOGY, 2013, 16 (01) : 17 - 22Arpaia, Nicholas论文数: 0 引用数: 0 h-index: 0机构: Mem Sloan Kettering Canc Ctr, Program Immunol, New York, NY 10065 USA Mem Sloan Kettering Canc Ctr, Program Immunol, New York, NY 10065 USABarton, Gregory M.论文数: 0 引用数: 0 h-index: 0机构: Univ Calif Berkeley, Dept Mol & Cell Biol, Div Immunol & Pathogenesis, Berkeley, CA 94720 USA Mem Sloan Kettering Canc Ctr, Program Immunol, New York, NY 10065 USA
- [9] Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-κB[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (19) : 12955 - 12958Bertin, J论文数: 0 引用数: 0 h-index: 0机构: Millennium Pharmaceut Inc, Cambridge, MA 02139 USA Millennium Pharmaceut Inc, Cambridge, MA 02139 USANir, WJ论文数: 0 引用数: 0 h-index: 0机构: Millennium Pharmaceut Inc, Cambridge, MA 02139 USA Millennium Pharmaceut Inc, Cambridge, MA 02139 USAFischer, CM论文数: 0 引用数: 0 h-index: 0机构: Millennium Pharmaceut Inc, Cambridge, MA 02139 USA Millennium Pharmaceut Inc, Cambridge, MA 02139 USATayber, OV论文数: 0 引用数: 0 h-index: 0机构: Millennium Pharmaceut Inc, Cambridge, MA 02139 USA Millennium Pharmaceut Inc, Cambridge, MA 02139 USAErrada, PR论文数: 0 引用数: 0 h-index: 0机构: Millennium Pharmaceut Inc, Cambridge, MA 02139 USA Millennium Pharmaceut Inc, Cambridge, MA 02139 USAGrant, JR论文数: 0 引用数: 0 h-index: 0机构: Millennium Pharmaceut Inc, Cambridge, MA 02139 USA Millennium Pharmaceut Inc, Cambridge, MA 02139 USAKeilty, JJ论文数: 0 引用数: 0 h-index: 0机构: Millennium Pharmaceut Inc, Cambridge, MA 02139 USA Millennium Pharmaceut Inc, Cambridge, MA 02139 USAGosselin, ML论文数: 0 引用数: 0 h-index: 0机构: Millennium Pharmaceut Inc, Cambridge, MA 02139 USA Millennium Pharmaceut Inc, Cambridge, MA 02139 USARobison, KE论文数: 0 引用数: 0 h-index: 0机构: Millennium Pharmaceut Inc, Cambridge, MA 02139 USA Millennium Pharmaceut Inc, Cambridge, MA 02139 USAWong, GHW论文数: 0 引用数: 0 h-index: 0机构: Millennium Pharmaceut Inc, Cambridge, MA 02139 USA Millennium Pharmaceut Inc, Cambridge, MA 02139 USAGlucksmann, MA论文数: 0 引用数: 0 h-index: 0机构: Millennium Pharmaceut Inc, Cambridge, MA 02139 USA Millennium Pharmaceut Inc, Cambridge, MA 02139 USADiStefano, PS论文数: 0 引用数: 0 h-index: 0机构: Millennium Pharmaceut Inc, Cambridge, MA 02139 USA Millennium Pharmaceut Inc, Cambridge, MA 02139 USA
- [10] Beyond pattern recognition: five immune checkpoints for scaling the microbial threat[J]. NATURE REVIEWS IMMUNOLOGY, 2012, 12 (03) : 215 - 225Blander, J. Magarian论文数: 0 引用数: 0 h-index: 0机构: Mt Sinai Sch Med, Inst Immunol, Dept Med, New York, NY 10029 USA Mt Sinai Sch Med, Inst Immunol, Dept Med, New York, NY 10029 USASander, Leif E.论文数: 0 引用数: 0 h-index: 0机构: Charite, Dept Infect Dis & Pulm Med, D-10117 Berlin, Germany Mt Sinai Sch Med, Inst Immunol, Dept Med, New York, NY 10029 USA