Low dose MK-801 protects against iron-induced oxidative changes in a rat model of focal epilepsy

被引:28
作者
Küçükkaya, B
Aker, R
Yüksel, M
Onat, F
Yalçin, AS
机构
[1] Marmara Univ, Fac Med, Dept Biochem, Istanbul, Turkey
[2] Marmara Univ, Fac Med, Dept Pharmacol, Istanbul, Turkey
关键词
chemiluminescence; MK-801; iron-induced epilepsy; oxidative changes;
D O I
10.1016/S0006-8993(97)01544-8
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We have used chemiluminescence measurements to examine the relationship between free radical formation and excitotoxicity in a post-traumatic epilepsy model. For this purpose, seven days after injecting iron in rat brain cortices, we measured luminol-and lucigenin-enhanced chemiluminescence in different brain regions (ipsilateral cortex, contralateral cortex, hypothalamus and hippocampus), In all brain regions (except contralateral cortices) both luminol- and lucigenin-enhanced chemiluminescence were increased in iron-injected group compared to saline-injected control group. These increases returned to control values in iron-injected rats pretreated with MK-801. Our results suggest that both free radicals and excitatory amino acids play important roles in the development of post-traumatic epilepsy and that MK-801 has protective effects against iron-induced chemiluminescence formation. (C) 1998 Elsevier Science B.V.
引用
收藏
页码:133 / 136
页数:4
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