Theobromine enhances absorption of cacao polyphenol in rats

被引：9
作者：
Yamamoto, Takayuki [1 ,2 ]
Takahashi, Haruya [1 ]
Suzuki, Koichiro [2 ]
Hirano, Akira [2 ]
Kamei, Masanori [2 ]
Goto, Tsuyoshi [1 ]
Takahashi, Nobuyuki [1 ]
Kawada, Teruo [1 ]
机构：
[1] Kyoto Univ, Grad Sch Agr, Div Food Sci & Biotechnol, Lab Mol Funct Food, Uji, Kyoto, Japan
[2] Morinaga & Co Ltd, Res Inst, Yokohama, Kanagawa, Japan
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2014年 / 78卷 / 12期
关键词：
absorption; rat; theobromine; Caco-2; cacao polyphenol; (-)-EPICATECHIN METABOLITES; MASS-SPECTROMETRY; ORAL INGESTION; COCOA; TRANSPORT; HUMANS; PLASMA; CAFFEINE; OBESITY; CELLS;
D O I：
10.1080/09168451.2014.942252
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Several concentrations of theobromine (TB) and (-)-epicatechin (EC) were coadministered to rats, and plasma EC and its metabolites were determined using ultra-high-performance liquid chromatography-tandem mass spectrometry. It has been demonstrated that TB increases the absorption of EC in a dose-dependent manner. Cocoa powder had a similar effect, and the mechanism involved is not thought to depend on tight junctions.
引用
收藏
页码：2059 / 2063
页数：5
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