Molecular classification of aggressive B-cell lymphoma

被引:1
作者
Bojarczuk, Kamil [1 ]
Chapuy, Bjoern [1 ]
机构
[1] Univ Med Ctr Gottingen, Dept Hematol & Oncol, Gottingen, Germany
关键词
INTEGRATIVE ANALYSIS REVEALS; CENTRAL-NERVOUS-SYSTEM; GENE-EXPRESSION; DIAGNOSIS; FEATURES; SUBTYPES;
D O I
10.1097/HS9.0000000000000273
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Take home messages Sequencing-based approaches are readily used for molecular classifications of aggressive B-cell lymphomas. Genetic classifiers identify novel vulnerabilities and inform clinical trial designs. Genetically-distinct DLBCLs provide insights into unique lymphomagenesis, prognosis prediction and combination of targeted treatments.
引用
收藏
页码:116 / 118
页数:3
相关论文
共 20 条
[1]   Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling [J].
Alizadeh, AA ;
Eisen, MB ;
Davis, RE ;
Ma, C ;
Lossos, IS ;
Rosenwald, A ;
Boldrick, JG ;
Sabet, H ;
Tran, T ;
Yu, X ;
Powell, JI ;
Yang, LM ;
Marti, GE ;
Moore, T ;
Hudson, J ;
Lu, LS ;
Lewis, DB ;
Tibshirani, R ;
Sherlock, G ;
Chan, WC ;
Greiner, TC ;
Weisenburger, DD ;
Armitage, JO ;
Warnke, R ;
Levy, R ;
Wilson, W ;
Grever, MR ;
Byrd, JC ;
Botstein, D ;
Brown, PO ;
Staudt, LM .
NATURE, 2000, 403 (6769) :503-511
[2]   Targeted inhibition of PI3Kα/δ is synergistic with BCL-2 blockade in genetically defined subtypes of DLBCL [J].
Bojarczuk, Kamil ;
Wienand, Kirsty ;
Ryan, Jeremy A. ;
Chen, Linfeng ;
Villalobos-Ortiz, Mariana ;
Mandato, Elisa ;
Stachura, Joanna ;
Letai, Anthony ;
Lawton, Lee N. ;
Chapuy, Bjoern ;
Shipp, Margaret A. .
BLOOD, 2019, 133 (01) :70-80
[3]   Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes [J].
Chapuy, Bjoern ;
Stewart, Chip ;
Dunford, Andrew J. ;
Kim, Jaegil ;
Kamburov, Atanas ;
Redd, Robert A. ;
Lawrence, Mike S. ;
Roemer, Margaretha G. M. ;
Li, Amy J. ;
Ziepert, Marita ;
Staiger, Annette M. ;
Wala, Jeremiah A. ;
Ducar, Matthew D. ;
Leshchiner, Ignaty ;
Rheinbay, Ester ;
Taylor-Weiner, Amaro ;
Coughlin, Caroline A. ;
Hess, Julian M. ;
Pedamallu, Chandra S. ;
Livitz, Dimitri ;
Rosebrock, Daniel ;
Rosenberg, Mara ;
Tracy, Adam A. ;
Horn, Heike ;
van Hummelen, Paul ;
Feldman, Andrew L. ;
Link, Brian K. ;
Novak, Anne J. ;
Cerhan, James R. ;
Habermann, Thomas M. ;
Siebert, Reiner ;
Rosenwald, Andreas ;
Thorner, Aaron R. ;
Meyerson, Matthew L. ;
Golub, Todd R. ;
Beroukhim, Rameen ;
Wulf, Gerald G. ;
Ott, German ;
Rodig, Scott J. ;
Monti, Stefano ;
Neuberg, Donna S. ;
Loeffler, Markus ;
Pfreundschuh, Michael ;
Truemper, Lorenz ;
Getz, Gad ;
Shipp, Margaret A. .
NATURE MEDICINE, 2018, 24 (05) :679-+
[4]   Targetable genetic features of primary testicular and primary central nervous system lymphomas [J].
Chapuy, Bjoern ;
Roemer, Margaretha G. M. ;
Stewart, Chip ;
Tan, Yuxiang ;
Abo, Ryan P. ;
Zhang, Liye ;
Dunford, Andrew J. ;
Meredith, David M. ;
Thorner, Aaron R. ;
Jordanova, Ekaterina S. ;
Liu, Gang ;
Feuerhake, Friedrich ;
Ducar, Matthew D. ;
Illerhaus, Gerald ;
Gusenleitner, Daniel ;
Linden, Erica A. ;
Sun, Heather H. ;
Homer, Heather ;
Aono, Miyuki ;
Pinkus, Geraldine S. ;
Ligon, Azra H. ;
Ligon, Keith L. ;
Ferry, Judith A. ;
Freeman, Gordon J. ;
van Hummelen, Paul ;
Golub, Todd R. ;
Getz, Gad ;
Rodig, Scott J. ;
de Jong, Daphne ;
Monti, Stefano ;
Shipp, Margaret A. .
BLOOD, 2016, 127 (07) :869-881
[5]   Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma [J].
Green, Michael R. ;
Monti, Stefano ;
Rodig, Scott J. ;
Juszczynski, Przemyslaw ;
Currie, Treeve ;
O'Donnell, Evan ;
Chapuy, Bjoern ;
Takeyama, Kunihiko ;
Neuberg, Donna ;
Golub, Todd R. ;
Kutok, Jeffery L. ;
Shipp, Margaret A. .
BLOOD, 2010, 116 (17) :3268-3277
[6]   Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray [J].
Hans, CP ;
Weisenburger, DD ;
Greiner, TC ;
Gascoyne, RD ;
Delabie, J ;
Ott, G ;
Müller-Hermelink, HK ;
Campo, E ;
Braziel, RM ;
Jaffe, ES ;
Pan, ZG ;
Farinha, P ;
Smith, LM ;
Falini, B ;
Banham, AH ;
Rosenwald, A ;
Staudt, LM ;
Connors, JM ;
Armitage, JO ;
Chan, WC .
BLOOD, 2004, 103 (01) :275-282
[7]   Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways [J].
Lenz, Georg ;
Wright, George W. ;
Emre, N. C. Tolga ;
Kohlhammer, Holger ;
Dave, Sandeep S. ;
Davis, R. Eric ;
Carty, Shannon ;
Lam, Lloyd T. ;
Shaffer, A. L. ;
Xiao, Wenming ;
Powell, John ;
Rosenwald, Andreas ;
Ott, German ;
Muller-Hermelink, Hans Konrad ;
Gascoyne, Randy D. ;
Connors, Joseph M. ;
Campo, Elias ;
Jaffe, Elaine S. ;
Delabie, Jan ;
Smeland, Erlend B. ;
Rimsza, Lisa M. ;
Fisher, Richard I. ;
Weisenburger, Dennis D. ;
Chan, Wing C. ;
Staudt, Louis M. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (36) :13520-13525
[8]   Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing [J].
Lohr, Jens G. ;
Stojanov, Petar ;
Lawrence, Michael S. ;
Auclair, Daniel ;
Chapuy, Bjoern ;
Sougnez, Carrie ;
Cruz-Gordillo, Peter ;
Knoechel, Birgit ;
Asmann, Yan W. ;
Slager, Susan L. ;
Novak, Anne J. ;
Dogan, Ahmet ;
Ansell, Stephen M. ;
Link, Brian K. ;
Zou, Lihua ;
Gould, Joshua ;
Saksena, Gordon ;
Stransky, Nicolas ;
Rangel-Escareno, Claudia ;
Carlos Fernandez-Lopez, Juan ;
Hidalgo-Miranda, Alfredo ;
Melendez-Zajgla, Jorge ;
Hernandez-Lemus, Enrique ;
Schwarz-Cruz y Celis, Angela ;
Imaz-Rosshandler, Ivan ;
Ojesina, Akinyemi I. ;
Jung, Joonil ;
Pedamallu, Chandra S. ;
Lander, Eric S. ;
Habermann, Thomas M. ;
Cerhan, James R. ;
Shipp, Margaret A. ;
Getz, Gad ;
Golub, Todd R. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (10) :3879-3884
[9]   Integrative Analysis Reveals an Outcome-Associated and Targetable Pattern of p53 and Cell Cycle Deregulation in Diffuse Large B Cell Lymphoma [J].
Monti, Stefano ;
Chapuy, Bjoern ;
Takeyama, Kunihiko ;
Rodig, Scott J. ;
Hao, Yansheng ;
Yeda, Kelly T. ;
Inguilizian, Haig ;
Mermel, Craig ;
Currie, Treeve ;
Dogan, Ahmet ;
Kutok, Jeffery L. ;
Beroukhim, Rameen ;
Neuberg, Donna ;
Habermann, Thomas M. ;
Getz, Gad ;
Kung, Andrew L. ;
Golub, Todd R. ;
Shipp, Margaret A. .
CANCER CELL, 2012, 22 (03) :359-372
[10]   Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma [J].
Morin, Ryan D. ;
Mendez-Lago, Maria ;
Mungall, Andrew J. ;
Goya, Rodrigo ;
Mungall, Karen L. ;
Corbett, Richard D. ;
Johnson, Nathalie A. ;
Severson, Tesa M. ;
Chiu, Readman ;
Field, Matthew ;
Jackman, Shaun ;
Krzywinski, Martin ;
Scott, David W. ;
Trinh, Diane L. ;
Tamura-Wells, Jessica ;
Li, Sa ;
Firme, Marlo R. ;
Rogic, Sanja ;
Griffith, Malachi ;
Chan, Susanna ;
Yakovenko, Oleksandr ;
Meyer, Irmtraud M. ;
Zhao, Eric Y. ;
Smailus, Duane ;
Moksa, Michelle ;
Chittaranjan, Suganthi ;
Rimsza, Lisa ;
Brooks-Wilson, Angela ;
Spinelli, John J. ;
Ben-Neriah, Susana ;
Meissner, Barbara ;
Woolcock, Bruce ;
Boyle, Merrill ;
McDonald, Helen ;
Tam, Angela ;
Zhao, Yongjun ;
Delaney, Allen ;
Zeng, Thomas ;
Tse, Kane ;
Butterfield, Yaron ;
Birol, Inanc ;
Holt, Rob ;
Schein, Jacqueline ;
Horsman, Douglas E. ;
Moore, Richard ;
Jones, Steven J. M. ;
Connors, Joseph M. ;
Hirst, Martin ;
Gascoyne, Randy D. ;
Marra, Marco A. .
NATURE, 2011, 476 (7360) :298-303