Immunological mechanisms of human resistance to persistent Mycobacterium tuberculosis infection

被引：212

作者：

Simmons, Jason D. ^{[1
]}

Stein, Catherine M. ^{[2
,3
]}

Seshadri, Chetan ^{[1
]}

Campo, Monica ^{[1
]}

Alter, Galit ^{[4
]}

Fortune, Sarah ^{[5
]}

Schurr, Erwin ^{[6
]}

Wallis, Robert S. ^{[3
,7
]}

Churchyard, Gavin ^{[7
]}

Mayanja-Kizza, Harriet ^{[8
]}

Boom, W. Henry ^{[3
]}

Hawn, Thomas R. ^{[1
]}

机构：

[1] Univ Washington, Dept Med, Seattle, WA 98195 USA

[2] Case Western Reserve Univ, Dept Populat & Quantitat Hlth Sci, Cleveland, OH 44106 USA

[3] Case Western Reserve Univ, Dept Med, Cleveland, OH 44106 USA

[4] Ragon Inst MGH MIT & Harvard, Cambridge, MA USA

[5] Harvard Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA USA

[6] McGill Univ, Ctr Hlth, Res Inst, Program Infect Dis & Immun Global Hlth, Montreal, PQ, Canada

[7] Aurum Inst, Parktown, South Africa

[8] Makerere Univ, Sch Med, Dept Med, Kampala, Uganda

来源：

NATURE REVIEWS IMMUNOLOGY | 2018年 / 18卷 / 09期

基金：

美国国家卫生研究院; 英国医学研究理事会; 加拿大健康研究院;

关键词：

TOLL-INTERACTING PROTEIN; INVARIANT T-CELLS; IFN-GAMMA; B-CELLS; PULMONARY TUBERCULOSIS; GENETIC SUSCEPTIBILITY; ACTIVE TUBERCULOSIS; HUMORAL IMMUNITY; INTERFERON-GAMMA; HIV-1; INFECTION;

D O I：

10.1038/s41577-018-0025-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mycobacterium tuberculosis is a leading cause of mortality worldwide and establishes a long-lived latent infection in a substantial proportion of the human population. Multiple lines of evidence suggest that some individuals are resistant to latent M. tuberculosis infection despite long-term and intense exposure, and we term these individuals 'resisters'. In this Review, we discuss the epidemiological and genetic data that support the existence of resisters and propose criteria to optimally define and characterize the resister phenotype. We review recent insights into the immune mechanisms of M. tuberculosis clearance, including responses mediated by macrophages, T cells and B cells. Understanding the cellular mechanisms that underlie resistance to M. tuberculosis infection may reveal immune correlates of protection that could be utilized for improved diagnostics, vaccine development and novel host-directed therapeutic strategies.

引用

页码：575 / 589

页数：15

共 176 条

[1] Alterations in the peripheral blood B cell subpopulations of multidrug-resistant tuberculosis patients
Abreu, Monica T.
Carvalheiro, Helena
Rodrigues-Sousa, Tiago
Domingos, Antonio
Segorbe-Luis, Antonio
Rodrigues-Santos, Paulo
Margarida Souto-Carneiro, M.
[J]. CLINICAL AND EXPERIMENTAL MEDICINE, 2014, 14 (04) : 423 - 429
[2] B cells and antibodies in the defense against Mycobacterium tuberculosis infection
Achkar, Jacqueline M.
Chan, John
Casadevall, Arturo
[J]. IMMUNOLOGICAL REVIEWS, 2015, 264 (01) : 167 - 181
[3] Mycobacterium tuberculosis strains with the Beijing genotype demonstrate variability in virulence associated with transmission
Aguilar L, D.
Hanekom, M.
Mata, D.
Gey van Pittius, N. C.
van Helden, P. D.
Warren, R. M.
Hernandez-Pando, R.
[J]. TUBERCULOSIS, 2010, 90 (05) : 319 - 325
[4] Tuberculosis among student nurses: A five year study at Bellevue hospital
Amberson, JB
Riggins, HM
[J]. ANNALS OF INTERNAL MEDICINE, 1936, 10 (02) : 156 - 165
[5] Modeling the Role of Public Transportation in Sustaining Tuberculosis Transmission in South Africa
Andrews, Jason R.
Morrow, Carl
Wood, Robin
[J]. AMERICAN JOURNAL OF EPIDEMIOLOGY, 2013, 177 (06) : 556 - 561
[6] [Anonymous], AM REV TUBERC
[7] [Anonymous], ZENTRALBLATT BAKTERI
[8] TLR4 mutations are associated with endotoxin hyporesponsiveness in humans
Arbour, NC
Lorenz, E
Schutte, BC
Zabner, J
Kline, JN
Jones, M
Frees, K
Watt, JL
Schwartz, DA
[J]. NATURE GENETICS, 2000, 25 (02) : 187 - +
[9] Innate Immune Gene Polymorphisms in Tuberculosis
Azad, Abul K.
Sadee, Wolfgang
Schlesinger, Larry S.
[J]. INFECTION AND IMMUNITY, 2012, 80 (10) : 3343 - 3359
[10] AZIZ A, 1985, JPMA (Journal of the Pakistan Medical Association), V35, P249

← 1 2 3 4 5 6 7 8 9 10 →