LINC00943 is correlated with gastric cancer and regulates cancer cell proliferation and chemosensitivity via hsa-miR-101-3p

被引:20
|
作者
Xu, Yan [1 ]
Ji, Tongzhen [2 ]
An, Ning [1 ]
Wang, Xiuling [1 ,3 ]
Zhang, Hui [4 ]
Xu, Fengliang [4 ]
机构
[1] Rizhao Cent Hosp, Dept Clin Lab, Rizhao 276800, Shandong, Peoples R China
[2] Rizhao TB Control Inst, TB Dept, Rizhao 276800, Shandong, Peoples R China
[3] Rizhao Peoples Hosp, Dept Clin Lab, Rizhao 276800, Shandong, Peoples R China
[4] Rizhao Peoples Hosp, Dept Endocrinol, Rizhao 276800, Shandong, Peoples R China
关键词
Gastric cancer; Non-coding RNA; LINC00943; miRNA; miR-101; 5-FU; LONG NONCODING RNAS; METASTASIS; PROGNOSIS; NETWORKS;
D O I
10.1007/s10147-021-01945-5
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background Non-coding RNAs have emerged as important regulators in human cancers. In this work, we investigated the role of long intergenic non-protein-coding RNA 943 (LINC00943) in gastric cancer (GC). Methods LINC00943 expression was evaluated in GC patient tissues and cell lines. In SNU-5 and MKN-45 cells, LINC00943 was knocked down to investigate its roles in regulating GC cell proliferation, 5-FU chemosensitivity and in vivo explant growth. Possible downstream target of LINC00943, human mature microRNA-101-3p (hsa-miR-101-3p) was also evaluated. Results LINC00943 was aberrantly overexpressed in in situ GC tumors and immortal GC cell lines. LINC00943 overexpression was associated with GC patients' poor prognosis. LINC00943 knockdown reduced GC cell proliferation, 5-FU resistance and in vivo explant growth. Hsa-miR-101-3p was found to be regulated by LINC00943 in GC. Hsa-miR-101-3p downregulation reversed the tumor-suppressing functions of LINC00943 knockdown in GC cells. Conclusion In summary, our results indicated that LINC00943 was correlated with gastric cancer and regulates cancer cell proliferation and chemosensitivity via hsa-miR-101-3p.
引用
收藏
页码:1650 / 1660
页数:11
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