Ni(II)-Catalyzed C(sp2)-H Alkynylation/Annulation with Terminal Alkynes under an Oxygen Atmosphere: A One-Pot Approach to 3-Methyleneisoindolin-1-one

被引：71

作者：

Zheng, Xin-Xiang ^{[1
]}

Du, Cong ^{[1
]}

Zhao, Xue-Mei ^{[1
]}

Zhu, Xinju ^{[1
]}

Suo, Jian-Feng ^{[1
]}

Hao, Xin-Qi ^{[1
]}

Niu, Jun-Long ^{[1
]}

Song, Mao-Ping ^{[1
]}

机构：

[1] Zhengzhou Univ, Coll Chem & Mol Engn, Zhengzhou 450001, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 81卷 / 10期

基金：

中国国家自然科学基金;

关键词：

C-H BONDS; 1ST TOTAL-SYNTHESIS; ALIPHATIC AMIDES; OXIDATIVE ALKENYLATION/ANNULATION; STEREOSELECTIVE-SYNTHESIS; CATALYZED CYCLIZATION; ANNULATION; ACTIVATION; C(SP(3))-H; ALKENES;

D O I：

10.1021/acs.joc.6b00129

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A nickel(II)-catalyzed alkynylation/annulation cascade via double C-H cleavage has been successfully achieved. This methodology adopted a removable N,O-bidentate directing group with a broad range of amide substrates and terminal alkynes being well tolerated. The catalytic system allowed for atom-economical and environmentally benign one-pot construction of the corresponding 3-methyleneisoindolin-1-one derivatives using O-2 as the external oxidant.

引用

页码：4002 / 4011

页数：10

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