Atrial fibrillation: Adverse effects of "pill-in-the-pocket" treatment and propafenone-carvedilol interaction

被引：5

作者：

Boriani, Giuseppe ^{[1
]}

Biffi, Mauro ^{[1
]}

Diemberger, Igor ^{[1
]}

Domenichini, Giulia ^{[1
]}

Marziali, Alessandro ^{[1
]}

Martignani, Cristian ^{[1
]}

机构：

[1] Univ Bologna, Inst Cardiol, Azienda Osped S Orsola Malpighi, Bologna, Italy

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 2010年 / 140卷 / 02期

关键词：

Atrial fibrillation; Carvedilol; Pharmacokinetics; Propafenone; CONVERSION;

D O I：

10.1016/j.ijcard.2008.11.028

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Propafenone and carvedilol share a common hepatic metabolism involving the oxidative pathway (CYP2D6). Therefore, oral loading with propafenone (as "pill-in-the-pocket" treatment of recent-onset atrial fibrillation) in a patient on concurrent carvedilol treatment may lead to a pharmacokinetic interaction, with high plasma levels of propafenone and potential drug-related adverse effects. In clinical practice, in order to improve the safety of "pill-in-the-pocket" treatment, use of propafenone loading should, in our view, be discouraged in patients on concurrent treatment with carvedilol. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

收藏

页码：242 / 243

页数：2

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