Clinical associations and mechanisms of action of antisperm antibodies

被引：73
作者：
Chiu, WWC [1 ]
Chamley, LW [1 ]
机构：
[1] Univ Auckland, Dept Obstet & Gynecol, Auckland 3, New Zealand
来源：
FERTILITY AND STERILITY | 2004年 / 82卷 / 03期
关键词：
assisted reproductive technology; fertilization; gamete biology; immunology; sperm;
D O I：
10.1016/j.fertnstert.2003.09.084
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objective: To review and critique the current English literature describing the effects of antisperm antibodies (ASA) on mammalian fertility. Design: A comprehensive English language literature was searched using Medline and by hand-searching. Emphasis was placed on clinically relevant articles. Result(s): Results from the studies were extrapolated and the effects of ASA on fertility described. Conclusion(s): Antisperm antibodies may interfere with fertility. Not all ASA cause infertility. Current tests cannot differentiate the infertility-related ASA from those that do not interfere with infertility, because the antigenic specificities of these ASA are not known. The antigens which the infertility-related ASA must be characterized to allow an accurate detection and proper treatment for couples with ASA. (C) 2004 by American Society for Reproductive Medicine.
引用
收藏
页码：529 / 535
页数：7
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