Beneficial Effect of Metformin on Nerve Regeneration and Functional Recovery After Sciatic Nerve Crush Injury in Diabetic Rats

被引：19
作者：
Ma, Junxiong [1 ]
Liu, Jun [1 ]
Yu, Hailong [1 ]
Chen, Yu [1 ]
Wang, Qi [1 ]
Xiang, Liangbi [1 ]
机构：
[1] Rescue Ctr Severe Wound & Trauma Chinese PLA, Gen Hosp Shenyang Mil Area Command Chinese PLA, Dept Orthoped, Shenyang 110016, Liaoning, Peoples R China
来源：
NEUROCHEMICAL RESEARCH | 2016年 / 41卷 / 05期
基金：
中国国家自然科学基金;
关键词：
Metformin; Nerve regeneration; Functional recovery; Sciatic nerve injury; Neuroprotective; SYNTHETIC OXYGEN CARRIER; FIBER REGENERATION; PERIPHERAL-NERVES; STREPTOZOTOCIN; REVEALS; MODEL; PAIN;
D O I：
10.1007/s11064-015-1803-y
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Neuroprotective effects of metformin have been increasingly recognized in both diabetic and non-diabetic conditions. Thus far, no information has been available on the potential beneficial effects of metformin on peripheral nerve regeneration in diabetes mellitus. The present study was designed to investigate such a possibility. Diabetes was established by a single injection of streptozotocin at 50 mg/kg in rats. After sciatic nerve crush injury, the diabetic rats were intraperitoneally administrated daily for 4 weeks with metformin (30, 200 and 500 mg/kg), or normal saline, respectively. The axonal regeneration was investigated by morphometric analysis and retrograde labeling. The functional recovery was evaluated by electrophysiological studies and behavioral analysis. It was found that metformin significantly enhanced axonal regeneration and functional recovery compared to saline after sciatic nerve injury in diabetic rats. In addition, metformin at 200 and 500 mg/kg showed better performance than that at 30 mg/kg. Taken together, metformin is capable of promoting nerve regeneration after sciatic nerve injuries in diabetes mellitus, highlighting its therapeutic values for peripheral nerve injury repair in diabetes mellitus.
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收藏
页码：1130 / 1137
页数：8
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