Endosomes: Emerging Platforms for Integrin-Mediated FAK Signalling

被引：85

作者：

Alanko, Jonna ^{[1
]}

Ivaska, Johanna ^{[1
,2
]}

机构：

[1] Univ Turku, Turku Ctr Biotechnol, FIN-20520 Turku, Finland

[2] Univ Turku, Dept Biochem & Food Chem, FIN-20520 Turku, Finland

来源：

TRENDS IN CELL BIOLOGY | 2016年 / 26卷 / 06期

基金：

芬兰科学院; 欧洲研究理事会;

关键词：

FOCAL ADHESION KINASE; GROWTH-FACTOR; CELL-ADHESION; MIGRATION; RAB21; PROLIFERATION; TRAFFICKING; RECRUITMENT; ACTIVATION; PROTEINS;

D O I：

10.1016/j.tcb.2016.02.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Integrins are vital cell adhesion receptors with the ability to transmit extracellular matrix (ECM) cues to intracellular signalling pathways. ECM-integrin signalling regulates various cellular functions such as cell survival and movement. Integrin signalling has been considered to occur exclusively from adhesion sites at the plasma membrane (PM). However, recent data demonstrates integrin signalling also from endosomes. Integrin-mediated focal adhesion kinase (FAK) signalling is strongly dependent on integrin endocytosis, and endosomal FAK signalling facilitates cancer metastasis by supporting anchorage-independent growth and anoikis resistance. Here we discuss the possible mechanisms and functions of endosomal FAK signalling compared with its previously known roles in other cellular locations and discuss the potential of endosomal FAK as novel target for future cancer therapies.

引用

页码：391 / 398

页数：8

共 50 条

[1]

Alanko J., 2015, ENCY CELL BIOL, P211

[2] Integrin endosomal signalling suppresses anoikis [J].

Alanko, Jonna ;

Mai, Anja ;

Jacquemet, Guillaume ;

Schauer, Kristine ;

Kaukonen, Riina ;

Saari, Markku ;

Goud, Bruno ;

Ivaska, Johanna .

NATURE CELL BIOLOGY, 2015, 17 (11) :1412-1421

[3] Distinct Recycling of Active and Inactive ß1 Integrins [J].

Arjonen, Antti ;

Alanko, Jonna ;

Veltel, Stefan ;

Ivaska, Johanna .

TRAFFIC, 2012, 13 (04) :610-625

[4] Integrin trafficking at a glance [J].

Bridgewater, Rebecca E. ;

Norman, Jim C. ;

Caswell, Patrick T. .

JOURNAL OF CELL SCIENCE, 2012, 125 (16) :3695-3701

[5] Spatial and temporal regulation of focal adhesion kinase activity in living cells [J].

Cai, Xinming ;

Lietha, Daniel ;

Ceccarelli, Derek F. ;

Karginov, Andrei V. ;

Rajfur, Zenon ;

Jacobson, Ken ;

Hahn, Klaus M. ;

Eck, Michael J. ;

Schaller, Michael D. .

MOLECULAR AND CELLULAR BIOLOGY, 2008, 28 (01) :201-214

[6] Talins and kindlins: partners in integrin-mediated adhesion [J].

Calderwood, David A. ;

Campbell, Iain D. ;

Critchley, David R. .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2013, 14 (08) :503-517

[7] Rab-coupling protein coordinates recycling of α5β1 integrin and EGFR1 to promote cell migration in 3D microenvironments [J].

Caswell, Patrick T. ;

Chan, May ;

Lindsay, Andrew J. ;

McCaffrey, Mary W. ;

Boettiger, David ;

Norman, Jim C. .

JOURNAL OF CELL BIOLOGY, 2008, 183 (01) :143-155

[8] The PI(3)P interactome from a colon cancer cell [J].

Catimel, Bruno ;

Kapp, Eugene ;

Yin, Meng-Xin ;

Gregory, Mark ;

Wong, Leon S. -M. ;

Condron, Melanie ;

Church, Nicole ;

Kershaw, Nadia ;

Holmes, Andrew B. ;

Burgess, Antony W. .

JOURNAL OF PROTEOMICS, 2013, 82 :35-51

[9] Nuclear envelope-associated endosomes deliver surface proteins to the nucleus [J].

Chaumet, Alexandre ;

Wright, Graham D. ;

Seet, Sze Hwee ;

Tham, Keit Min ;

Gounko, Natalia V. ;

Bard, Frederic .

NATURE COMMUNICATIONS, 2015, 6

[10] Direct interaction of focal adhesion kinase (FAK) with Met is required for FAK to promote hepatocyte growth factor-induced cell invasion [J].

Chen, SY ;

Chen, HC .

MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (13) :5155-5167

← 1 2 3 4 5 →