A Study on single-dose oral toxicity of D-allose in ICR mice

D-Allose is a rare natural sugar, which is attractive as a sweetener alternative to sugar because of its biological functions and low-calorie content. However, there is a lack of basic information regarding the use of D-allose as a food ingredient. In this study D-allose toxicity to ICR mice was investigated. The mice were treated with a single dose of D-allose (1,250, 2,500 or 5,000 mg/kg body weight). No organ injury was observed, nor any changes observed in the clinical sign, body weight and the blood serum chemistry. The approximate lethal dose was estimated to exceed 5,000 mg/kg in mice. These results suggest that D-allose is practically non-toxic to mice.