Inherited determinants of early recurrent somatic mutations in prostate cancer

被引：24

作者：

Romanel, Alessandro ^{[1
]}

Garritano, Sonia ^{[1
]}

Stringa, Blerta ^{[1
]}

Blattner, Mirjam ^{[1
]}

Dalfovo, Davide ^{[1
]}

Chakravarty, Dimple ^{[2
]}

Soong, David ^{[3
]}

Cotter, Kellie A. ^{[2
]}

Petris, Gianluca ^{[1
]}

Dhingra, Priyanka ^{[3
]}

Gasperini, Paola ^{[1
]}

Cereseto, Anna ^{[1
]}

Elemento, Olivier ^{[2
,3
]}

Sboner, Andrea ^{[2
]}

Khurana, Ekta ^{[2
]}

Inga, Alberto ^{[1
]}

Rubin, Mark A. ^{[2
,4
,5
]}

Demichelis, Francesca ^{[1
,2
]}

机构：

[1] Univ Trento, Ctr Integrat Biol, Via Sommarive 9, I-38123 Trento, Italy

[2] Weill Cornell Med, Caryl & Israel Englander Inst Precis Med, New York Presbyterian Hosp, 413 East 69th St, New York, NY 10021 USA

[3] Weill Cornell Med, Dept Physiol & Biophys, 1300 York Ave, New York, NY 10065 USA

[4] Weill Cornell Med, Dept Pathol & Lab Med, 1300 York Ave, New York, NY 10065 USA

[5] Weill Cornell Med, Sandra & Edward Meyer Canc Ctr, 1300 York Ave, New York, NY 10065 USA

来源：

NATURE COMMUNICATIONS | 2017年 / 8卷

关键词：

BINDING; GENE; RISK; SPOP; IDENTIFICATION; ASSOCIATION; FREQUENCY; VARIANTS; TMPRSS2; FUSION;

D O I：

10.1038/s41467-017-00046-0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Prostate cancer is a highly heritable molecularly and clinically heterogeneous disease. To discover germline events involved in prostate cancer predisposition, we develop a computational approach to nominate heritable facilitators of somatic genomic events in the context of the androgen receptor signaling. Here, we use a ranking score and benign prostate transcriptomes to identify a non-coding polymorphic regulatory element at 7p14.3 that associates with DNA repair and hormone-regulated transcript levels and with an early recurrent prostate cancer-specific somatic mutation in the Speckle-Type POZ protein (SPOP) gene. The locus shows allele-specific activity that is concomitantly modulated by androgen receptor and by CCAAT/enhancer-binding protein (C/EBP) beta (CEBPB). Deletion of this locus via CRISPR-Cas9 leads to deregulation of the genes predicted to interact with the 7p14.3 locus by Hi-C chromosome conformation capture data. This study suggests that a polymorphism at 7p14.3 may predispose to SPOP mutant prostate cancer subclass through a hormone-dependent DNA damage response.

引用

页数：10

共 43 条

[1] The Molecular Taxonomy of Primary Prostate Cancer [J].

Abeshouse, Adam ;

Ahn, Jaeil ;

Akbani, Rehan ;

Ally, Adrian ;

Amin, Samirkumar ;

Andry, Christopher D. ;

Annala, Matti ;

Aprikian, Armen ;

Armenia, Joshua ;

Arora, Arshi ;

Auman, J. Todd ;

Balasundaram, Miruna ;

Balu, Saianand ;

Barbieri, Christopher E. ;

Bauer, Thomas ;

Benz, Christopher C. ;

Bergeron, Alain ;

Beroukhim, Rameen ;

Berrios, Mario ;

Bivol, Adrian ;

Bodenheimer, Tom ;

Boice, Lori ;

Bootwalla, Moiz S. ;

dos Reis, Rodolfo Borges ;

Boutros, Paul C. ;

Bowen, Jay ;

Bowlby, Reanne ;

Boyd, Jeffrey ;

Bradley, Robert K. ;

Breggia, Anne ;

Brimo, Fadi ;

Bristow, Christopher A. ;

Brooks, Denise ;

Broom, Bradley M. ;

Bryce, Alan H. ;

Bubley, Glenn ;

Burks, Eric ;

Butterfield, Yaron S. N. ;

Button, Michael ;

Canes, David ;

Carlotti, Carlos G. ;

Carlsen, Rebecca ;

Carmel, Michel ;

Carroll, Peter R. ;

Carter, Scott L. ;

Cartun, Richard ;

Carver, Brett S. ;

Chan, June M. ;

Chang, Matthew T. ;

Chen, Yu .

CELL, 2015, 163 (04) :1011-1025

[2] A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer [J].

Al Olama, Ali Amin ;

Kote-Jarai, Zsofia ;

Berndt, Sonja I. ;

Conti, David V. ;

Schumacher, Fredrick ;

Han, Ying ;

Benlloch, Sara ;

Hazelett, Dennis J. ;

Wang, Zhaoming ;

Saunders, Ed ;

Leongamornlert, Daniel ;

Lindstrom, Sara ;

Jugurnauth-Little, Sara ;

Dadaev, Tokhir ;

Tymrakiewicz, Malgorzata ;

Stram, Daniel O. ;

Rand, Kristin ;

Wan, Peggy ;

Stram, Alex ;

Sheng, Xin ;

Pooler, Loreall C. ;

Park, Karen ;

Xia, Lucy ;

Tyrer, Jonathan ;

Kolonel, Laurence N. ;

Le Marchand, Loic ;

Hoover, Robert N. ;

Machiela, Mitchell J. ;

Yeager, Merideth ;

Burdette, Laurie ;

Chung, Charles C. ;

Hutchinson, Amy ;

Yu, Kai ;

Goh, Chee ;

Ahmed, Mahbubl ;

Govindasami, Koveela ;

Guy, Michelle ;

Tammela, Teuvo L. J. ;

Auvinen, Anssi ;

Wahlfors, Tlina ;

Schleutker, Johanna ;

Visakorpi, Tapio ;

Leinonen, Katri A. ;

Xu, Jianfeng ;

Aly, Markus ;

Donovan, Jenny ;

Travis, Ruth C. ;

Key, Tim J. ;

Siddiq, Afshan ;

Canzian, Federico .

NATURE GENETICS, 2014, 46 (10) :1103-1109

[3] Punctuated Evolution of Prostate Cancer Genomes [J].

Baca, Sylvan C. ;

Prandi, Davide ;

Lawrence, Michael S. ;

Mosquera, Juan Miguel ;

Romanel, Alessandro ;

Drier, Yotam ;

Park, Kyung ;

Kitabayashi, Naoki ;

MacDonald, Theresa Y. ;

Ghandi, Mahmoud ;

Van Allen, Eliezer ;

Kryukov, Gregory V. ;

Sboner, Andrea ;

Theurillat, Jean-Philippe ;

Soong, T. David ;

Nickerson, Elizabeth ;

Auclair, Daniel ;

Tewari, Ashutosh ;

Beltran, Himisha ;

Onofrio, Robert C. ;

Boysen, Gunther ;

Guiducci, Candace ;

Barbieri, Christopher E. ;

Cibulskis, Kristian ;

Sivachenko, Andrey ;

Carter, Scott L. ;

Saksena, Gordon ;

Voet, Douglas ;

Ramos, Alex H. ;

Winckler, Wendy ;

Cipicchio, Michelle ;

Ardlie, Kristin ;

Kantoff, Philip W. ;

Berger, Michael F. ;

Gabriel, Stacey B. ;

Golub, Todd R. ;

Meyerson, Matthew ;

Lander, Eric S. ;

Elemento, Olivier ;

Getz, Gad ;

Demichelis, Francesca ;

Rubin, Mark A. ;

Garraway, Levi A. .

CELL, 2013, 153 (03) :666-677

[4] Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer [J].

Barbieri, Christopher E. ;

Baca, Sylvan C. ;

Lawrence, Michael S. ;

Demichelis, Francesca ;

Blattner, Mirjam ;

Theurillat, Jean-Philippe ;

White, Thomas A. ;

Stojanov, Petar ;

Van Allen, Eliezer ;

Stransky, Nicolas ;

Nickerson, Elizabeth ;

Chae, Sung-Suk ;

Boysen, Gunther ;

Auclair, Daniel ;

Onofrio, Robert C. ;

Park, Kyung ;

Kitabayashi, Naoki ;

MacDonald, Theresa Y. ;

Sheikh, Karen ;

Vuong, Terry ;

Guiducci, Candace ;

Cibulskis, Kristian ;

Sivachenko, Andrey ;

Carter, Scott L. ;

Saksena, Gordon ;

Voet, Douglas ;

Hussain, Wasay M. ;

Ramos, Alex H. ;

Winckler, Wendy ;

Redman, Michelle C. ;

Ardlie, Kristin ;

Tewari, Ashutosh K. ;

Mosquera, Juan Miguel ;

Rupp, Niels ;

Wild, Peter J. ;

Moch, Holger ;

Morrissey, Colm ;

Nelson, Peter S. ;

Kantoff, Philip W. ;

Gabriel, Stacey B. ;

Golub, Todd R. ;

Meyerson, Matthew ;

Lander, Eric S. ;

Getz, Gad ;

Rubin, Mark A. ;

Garraway, Levi A. .

NATURE GENETICS, 2012, 44 (06) :685-U107

[5] The genomic complexity of primary human prostate cancer [J].

Berger, Michael F. ;

Lawrence, Michael S. ;

Demichelis, Francesca ;

Drier, Yotam ;

Cibulskis, Kristian ;

Sivachenko, Andrey Y. ;

Sboner, Andrea ;

Esgueva, Raquel ;

Pflueger, Dorothee ;

Sougnez, Carrie ;

Onofrio, Robert ;

Carter, Scott L. ;

Park, Kyung ;

Habegger, Lukas ;

Ambrogio, Lauren ;

Fennell, Timothy ;

Parkin, Melissa ;

Saksena, Gordon ;

Voet, Douglas ;

Ramos, Alex H. ;

Pugh, Trevor J. ;

Wilkinson, Jane ;

Fisher, Sheila ;

Winckler, Wendy ;

Mahan, Scott ;

Ardlie, Kristin ;

Baldwin, Jennifer ;

Simons, Jonathan W. ;

Kitabayashi, Naoki ;

MacDonald, Theresa Y. ;

Kantoff, Philip W. ;

Chin, Lynda ;

Gabriel, Stacey B. ;

Gerstein, Mark B. ;

Golub, Todd R. ;

Meyerson, Matthew ;

Tewari, Ashutosh ;

Lander, Eric S. ;

Getz, Gad ;

Rubin, Mark A. ;

Garraway, Levi A. .

NATURE, 2011, 470 (7333) :214-220

[6] SPOP Mutations in Prostate Cancer across Demographically Diverse Patient Cohorts [J].

Blattner, Mirjam ;

Lee, Daniel J. ;

O'Reilly, Catherine ;

Park, Kyung ;

MacDonald, Theresa Y. ;

Khani, Francesca ;

Turner, Kevin R. ;

Chiu, Ya-Lin ;

Wild, Peter J. ;

Dolgalev, Igor ;

Heguy, Adriana ;

Sboner, Andrea ;

Ramazangolu, Sinan ;

Hieronymus, Haley ;

Sawyers, Charles ;

Tewari, Ashutosh K. ;

Moch, Holger ;

Yoon, Ghil Suk ;

Known, Yong Chul ;

Andren, Ove ;

Fall, Katja ;

Demichelis, Francecsa ;

Mosquera, Juan Miguel ;

Robinson, Brian D. ;

Barbieri, Christopher E. ;

Rubin, Mark A. .

NEOPLASIA, 2014, 16 (01) :14-U34

[7] SPOP mutation leads to genomic instability in prostate cancer [J].

Boysen, Gunther ;

Barbieri, Christopher E. ;

Prandi, Davide ;

Blattner, Mirjam ;

Chae, Sung-Suk ;

Dahija, Arun ;

Nataraj, Srilakshmi ;

Huang, Dennis ;

Marotz, Clarisse ;

Xu, Limei ;

Huang, Julie ;

Lecca, Paola ;

Chhangawala, Sagar ;

Liu, Deli ;

Zhou, Pengbo ;

Sboner, Andrea ;

de Bono, Johann S. ;

Demichelis, Francesca ;

Houvras, Yariv ;

Rubin, Mark A. .

ELIFE, 2015, 4

[8] Putative Prostate Cancer Risk SNP in an Androgen Receptor-Binding Site of the Melanophilin Gene Illustrates Enrichment of Risk SNPs in Androgen Receptor Target Sites [J].

Bu, Huajie ;

Narisu, Narisu ;

Schlick, Bettina ;

Rainer, Johannes ;

Manke, Thomas ;

Schaefer, Georg ;

Pasqualini, Lorenza ;

Chines, Peter ;

Schweiger, Michal R. ;

Fuchsberger, Christian ;

Klocker, Helmut .

HUMAN MUTATION, 2016, 37 (01) :52-64

[9] The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer [J].

Chakravarty, Dimple ;

Sboner, Andrea ;

Nair, Sujit S. ;

Giannopoulou, Eugenia ;

Li, Ruohan ;

Hennig, Sven ;

Mosquera, Juan Miguel ;

Pauwels, Jonathan ;

Park, Kyung ;

Kossai, Myriam ;

MacDonald, Theresa Y. ;

Fontugne, Jacqueline ;

Erho, Nicholas ;

Vergara, Ismael A. ;

Ghadessi, Mercedeh ;

Davicioni, Elai ;

Jenkins, Robert B. ;

Palanisamy, Nallasivam ;

Chen, Zhengming ;

Nakagawa, Shinichi ;

Hirose, Tetsuro ;

Bander, Neil H. ;

Beltran, Himisha ;

Fox, Archa H. ;

Elemento, Olivier ;

Rubin, Mark A. .

NATURE COMMUNICATIONS, 2014, 5

[10] Androgen Regulation of the TMPRSS2 Gene and the Effect of a SNP in an Androgen Response Element [J].

Clinckemalie, Liesbeth ;

Spans, Lien ;

Dubois, Vanessa ;

Laurent, Michael ;

Helsen, Christine ;

Joniau, Steven ;

Claessens, Frank .

MOLECULAR ENDOCRINOLOGY, 2013, 27 (12) :2028-2040

← 1 2 3 4 5 →

共 43 条

[1] The Molecular Taxonomy of Primary Prostate Cancer [J].

Abeshouse, Adam ;

Ahn, Jaeil ;

Akbani, Rehan ;

Ally, Adrian ;

Amin, Samirkumar ;

Andry, Christopher D. ;

Annala, Matti ;

Aprikian, Armen ;

Armenia, Joshua ;

Arora, Arshi ;

Auman, J. Todd ;

Balasundaram, Miruna ;

Balu, Saianand ;

Barbieri, Christopher E. ;

Bauer, Thomas ;

Benz, Christopher C. ;

Bergeron, Alain ;

Beroukhim, Rameen ;

Berrios, Mario ;

Bivol, Adrian ;

Bodenheimer, Tom ;

Boice, Lori ;

Bootwalla, Moiz S. ;

dos Reis, Rodolfo Borges ;

Boutros, Paul C. ;

Bowen, Jay ;

Bowlby, Reanne ;

Boyd, Jeffrey ;

Bradley, Robert K. ;

Breggia, Anne ;

Brimo, Fadi ;

Bristow, Christopher A. ;

Brooks, Denise ;

Broom, Bradley M. ;

Bryce, Alan H. ;

Bubley, Glenn ;

Burks, Eric ;

Butterfield, Yaron S. N. ;

Button, Michael ;

Canes, David ;

Carlotti, Carlos G. ;

Carlsen, Rebecca ;

Carmel, Michel ;

Carroll, Peter R. ;

Carter, Scott L. ;

Cartun, Richard ;

Carver, Brett S. ;

Chan, June M. ;

Chang, Matthew T. ;

Chen, Yu .

CELL, 2015, 163 (04) :1011-1025

[2] A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer [J].

Al Olama, Ali Amin ;

Kote-Jarai, Zsofia ;

Berndt, Sonja I. ;

Conti, David V. ;

Schumacher, Fredrick ;

Han, Ying ;

Benlloch, Sara ;

Hazelett, Dennis J. ;

Wang, Zhaoming ;

Saunders, Ed ;

Leongamornlert, Daniel ;

Lindstrom, Sara ;

Jugurnauth-Little, Sara ;

Dadaev, Tokhir ;

Tymrakiewicz, Malgorzata ;

Stram, Daniel O. ;

Rand, Kristin ;

Wan, Peggy ;

Stram, Alex ;

Sheng, Xin ;

Pooler, Loreall C. ;

Park, Karen ;

Xia, Lucy ;

Tyrer, Jonathan ;

Kolonel, Laurence N. ;

Le Marchand, Loic ;

Hoover, Robert N. ;

Machiela, Mitchell J. ;

Yeager, Merideth ;

Burdette, Laurie ;

Chung, Charles C. ;

Hutchinson, Amy ;

Yu, Kai ;

Goh, Chee ;

Ahmed, Mahbubl ;

Govindasami, Koveela ;

Guy, Michelle ;

Tammela, Teuvo L. J. ;

Auvinen, Anssi ;

Wahlfors, Tlina ;

Schleutker, Johanna ;

Visakorpi, Tapio ;

Leinonen, Katri A. ;

Xu, Jianfeng ;

Aly, Markus ;

Donovan, Jenny ;

Travis, Ruth C. ;

Key, Tim J. ;

Siddiq, Afshan ;

Canzian, Federico .

NATURE GENETICS, 2014, 46 (10) :1103-1109

[3] Punctuated Evolution of Prostate Cancer Genomes [J].

Baca, Sylvan C. ;

Prandi, Davide ;

Lawrence, Michael S. ;

Mosquera, Juan Miguel ;

Romanel, Alessandro ;

Drier, Yotam ;

Park, Kyung ;

Kitabayashi, Naoki ;

MacDonald, Theresa Y. ;

Ghandi, Mahmoud ;

Van Allen, Eliezer ;

Kryukov, Gregory V. ;

Sboner, Andrea ;

Theurillat, Jean-Philippe ;

Soong, T. David ;

Nickerson, Elizabeth ;

Auclair, Daniel ;

Tewari, Ashutosh ;

Beltran, Himisha ;

Onofrio, Robert C. ;

Boysen, Gunther ;

Guiducci, Candace ;

Barbieri, Christopher E. ;

Cibulskis, Kristian ;

Sivachenko, Andrey ;

Carter, Scott L. ;

Saksena, Gordon ;

Voet, Douglas ;

Ramos, Alex H. ;

Winckler, Wendy ;

Cipicchio, Michelle ;

Ardlie, Kristin ;

Kantoff, Philip W. ;

Berger, Michael F. ;

Gabriel, Stacey B. ;

Golub, Todd R. ;

Meyerson, Matthew ;

Lander, Eric S. ;

Elemento, Olivier ;

Getz, Gad ;

Demichelis, Francesca ;

Rubin, Mark A. ;

Garraway, Levi A. .

CELL, 2013, 153 (03) :666-677

[4] Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer [J].

Barbieri, Christopher E. ;

Baca, Sylvan C. ;

Lawrence, Michael S. ;

Demichelis, Francesca ;

Blattner, Mirjam ;

Theurillat, Jean-Philippe ;

White, Thomas A. ;

Stojanov, Petar ;

Van Allen, Eliezer ;

Stransky, Nicolas ;

Nickerson, Elizabeth ;

Chae, Sung-Suk ;

Boysen, Gunther ;

Auclair, Daniel ;

Onofrio, Robert C. ;

Park, Kyung ;

Kitabayashi, Naoki ;

MacDonald, Theresa Y. ;

Sheikh, Karen ;

Vuong, Terry ;

Guiducci, Candace ;

Cibulskis, Kristian ;

Sivachenko, Andrey ;

Carter, Scott L. ;

Saksena, Gordon ;

Voet, Douglas ;

Hussain, Wasay M. ;

Ramos, Alex H. ;

Winckler, Wendy ;

Redman, Michelle C. ;

Ardlie, Kristin ;

Tewari, Ashutosh K. ;

Mosquera, Juan Miguel ;

Rupp, Niels ;

Wild, Peter J. ;

Moch, Holger ;

Morrissey, Colm ;

Nelson, Peter S. ;

Kantoff, Philip W. ;

Gabriel, Stacey B. ;

Golub, Todd R. ;

Meyerson, Matthew ;

Lander, Eric S. ;

Getz, Gad ;

Rubin, Mark A. ;

Garraway, Levi A. .

NATURE GENETICS, 2012, 44 (06) :685-U107

[5] The genomic complexity of primary human prostate cancer [J].

Berger, Michael F. ;

Lawrence, Michael S. ;

Demichelis, Francesca ;

Drier, Yotam ;

Cibulskis, Kristian ;

Sivachenko, Andrey Y. ;

Sboner, Andrea ;

Esgueva, Raquel ;

Pflueger, Dorothee ;

Sougnez, Carrie ;

Onofrio, Robert ;

Carter, Scott L. ;

Park, Kyung ;

Habegger, Lukas ;

Ambrogio, Lauren ;

Fennell, Timothy ;

Parkin, Melissa ;

Saksena, Gordon ;

Voet, Douglas ;

Ramos, Alex H. ;

Pugh, Trevor J. ;

Wilkinson, Jane ;

Fisher, Sheila ;

Winckler, Wendy ;

Mahan, Scott ;

Ardlie, Kristin ;

Baldwin, Jennifer ;

Simons, Jonathan W. ;

Kitabayashi, Naoki ;

MacDonald, Theresa Y. ;

Kantoff, Philip W. ;

Chin, Lynda ;

Gabriel, Stacey B. ;

Gerstein, Mark B. ;

Golub, Todd R. ;

Meyerson, Matthew ;

Tewari, Ashutosh ;

Lander, Eric S. ;

Getz, Gad ;

Rubin, Mark A. ;

Garraway, Levi A. .

NATURE, 2011, 470 (7333) :214-220

[6] SPOP Mutations in Prostate Cancer across Demographically Diverse Patient Cohorts [J].

Blattner, Mirjam ;

Lee, Daniel J. ;

O'Reilly, Catherine ;

Park, Kyung ;

MacDonald, Theresa Y. ;

Khani, Francesca ;

Turner, Kevin R. ;

Chiu, Ya-Lin ;

Wild, Peter J. ;

Dolgalev, Igor ;

Heguy, Adriana ;

Sboner, Andrea ;

Ramazangolu, Sinan ;

Hieronymus, Haley ;

Sawyers, Charles ;

Tewari, Ashutosh K. ;

Moch, Holger ;

Yoon, Ghil Suk ;

Known, Yong Chul ;

Andren, Ove ;

Fall, Katja ;

Demichelis, Francecsa ;

Mosquera, Juan Miguel ;

Robinson, Brian D. ;

Barbieri, Christopher E. ;

Rubin, Mark A. .

NEOPLASIA, 2014, 16 (01) :14-U34

[7] SPOP mutation leads to genomic instability in prostate cancer [J].

Boysen, Gunther ;

Barbieri, Christopher E. ;

Prandi, Davide ;

Blattner, Mirjam ;

Chae, Sung-Suk ;

Dahija, Arun ;

Nataraj, Srilakshmi ;

Huang, Dennis ;

Marotz, Clarisse ;

Xu, Limei ;

Huang, Julie ;

Lecca, Paola ;

Chhangawala, Sagar ;

Liu, Deli ;

Zhou, Pengbo ;

Sboner, Andrea ;

de Bono, Johann S. ;

Demichelis, Francesca ;

Houvras, Yariv ;

Rubin, Mark A. .

ELIFE, 2015, 4

[8] Putative Prostate Cancer Risk SNP in an Androgen Receptor-Binding Site of the Melanophilin Gene Illustrates Enrichment of Risk SNPs in Androgen Receptor Target Sites [J].

Bu, Huajie ;

Narisu, Narisu ;

Schlick, Bettina ;

Rainer, Johannes ;

Manke, Thomas ;

Schaefer, Georg ;

Pasqualini, Lorenza ;

Chines, Peter ;

Schweiger, Michal R. ;

Fuchsberger, Christian ;

Klocker, Helmut .

HUMAN MUTATION, 2016, 37 (01) :52-64

[9] The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer [J].

Chakravarty, Dimple ;

Sboner, Andrea ;

Nair, Sujit S. ;

Giannopoulou, Eugenia ;

Li, Ruohan ;

Hennig, Sven ;

Mosquera, Juan Miguel ;

Pauwels, Jonathan ;

Park, Kyung ;

Kossai, Myriam ;

MacDonald, Theresa Y. ;

Fontugne, Jacqueline ;

Erho, Nicholas ;

Vergara, Ismael A. ;

Ghadessi, Mercedeh ;

Davicioni, Elai ;

Jenkins, Robert B. ;

Palanisamy, Nallasivam ;

Chen, Zhengming ;

Nakagawa, Shinichi ;

Hirose, Tetsuro ;

Bander, Neil H. ;

Beltran, Himisha ;

Fox, Archa H. ;

Elemento, Olivier ;

Rubin, Mark A. .

NATURE COMMUNICATIONS, 2014, 5

[10] Androgen Regulation of the TMPRSS2 Gene and the Effect of a SNP in an Androgen Response Element [J].

Clinckemalie, Liesbeth ;

Spans, Lien ;

Dubois, Vanessa ;

Laurent, Michael ;

Helsen, Christine ;

Joniau, Steven ;

Claessens, Frank .

MOLECULAR ENDOCRINOLOGY, 2013, 27 (12) :2028-2040

← 1 2 3 4 5 →