Open Systems Pharmacology Community-An Open Access, Open Source, Open Science Approach to Modeling and Simulation in Pharmaceutical Sciences

被引：74

作者：

Lippert, Joerg ^{[1
]}

Burghaus, Rolf ^{[1
]}

Edginton, Andrea ^{[2
]}

Frechen, Sebastian ^{[1
]}

Karlsson, Mats ^{[3
]}

Kovar, Andreas ^{[4
]}

Lehr, Thorsten ^{[5
]}

Milligan, Peter ^{[6
]}

Nock, Valerie ^{[7
]}

Ramusovic, Sergej ^{[4
]}

Riggs, Matthew ^{[8
]}

Schaller, Stephan ^{[9
]}

Schlender, Jan ^{[1
]}

Schmidt, Stephan ^{[10
]}

Sevestre, Michael ^{[11
]}

Sjogren, Erik ^{[3
,6
]}

Solodenko, Juri ^{[1
]}

Staab, Alexander ^{[7
]}

Teutonico, Donato ^{[12
]}

机构：

[1] Bayer AG, Clin Pharmacometr, Wuppertal, Germany

[2] Univ Waterloo, Sch Pharm, Waterloo, ON, Canada

[3] Uppsala Univ, Fac Pharm, Uppsala, Sweden

[4] Sanofi Aventis, Pharmacokinet Dynam & Metab, Frankfurt, Germany

[5] Saarland Univ, Clin Pharm, Saarbrucken, Germany

[6] Pharmetheus, Uppsala, Sweden

[7] Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, Germany

[8] Metrum Res Grp, Tariffville, CT USA

[9] EsqLABS GmbH, Saterland, Germany

[10] Univ Florida, Coll Pharm, Orlando, FL USA

[11] Design2Code Inc, Waterloo, ON, Canada

[12] Sanofi Aventis R&D, Pharmacokinet Dynam & Metab, Alfortville, France

来源：

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY | 2019年 / 8卷 / 12期

基金：

欧盟地平线“2020”;

关键词：

D O I：

10.1002/psp4.12473

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Systems pharmacology integrates structural biological and pharmacological knowledge and experimental data, enabling dissection of organism and drug properties and providing excellent predictivity. The development of systems pharmacology models is a significant task requiring massive amounts of background information beyond individual trial data. The qualification of models needs repetitive demonstration of successful predictions. Open Systems Pharmacology is a community that develops, qualifies, and shares professional open source software tools and models in a collaborative open-science way.

引用

页码：878 / 882

页数：5

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