Isolated lymphomatoid granulomatosis of the central nervous system: A case report and literature review

被引：7

作者：

He, Chao ^{[1
]}

Wang, Yunxia ^{[1
]}

Zhang, Leyi ^{[1
]}

Lu, Chenglong ^{[1
]}

Ge, Wei ^{[1
]}

Zhang, Qingkui ^{[1
]}

Gui, Qiuping ^{[2
]}

Liu, Ruozhuo ^{[1
]}

Yu, Shengyuan ^{[1
]}

机构：

[1] Chinese Peoples Liberat Army Gen Hosp, Dept Neurol, 28 Fu Xing Rd, Beijing 100853, Peoples R China

[2] Chinese Peoples Liberat Army Gen Hosp, Dept Pathol, Beijing, Peoples R China

来源：

NEUROPATHOLOGY | 2019年 / 39卷 / 06期

基金：

中国国家自然科学基金;

关键词：

central nervous system; Epstein-Barr virus; human immunodeficiency virus; lymphomatoid granulomatosis; lymphoproliferative disorder; CHRONIC LYMPHOCYTIC INFLAMMATION; ANGIOCENTRIC IMMUNOPROLIFERATIVE LESIONS; B-CELL LYMPHOMA; MR; INVOLVEMENT; CNS; BRAIN; CT; REMISSION; DIAGNOSIS;

D O I：

10.1111/neup.12605

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Lymphomatoid granulomatosis (LYG) is an angiocentric and angiodestructive lymphoproliferative disease which can involve multiple organs of the body and is most common in the lungs. Its pathological features are proliferation of large atypical B-cells related to Epstein-Barr virus, T-cell infiltration and tissue necrosis. This disease is rare, and LYG which uniquely involves the central nervous system (CNS) is extremely rare. In this paper, we report a case of isolated lymphomatoid granulomatosis of the CNS (iCNS-LYG) diagnosed by histological biopsy and we review the clinical features of all similar cases reported in the past 46 years. A total of 49 cases of iCNS-LYG have been reported to date. The clinical, imaging and pathological features of iCNS-LYG are discussed in combination with a literature review.

引用

页码：479 / 488

页数：10

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