Assessing the impact of a joint human-porcine intervention package for Taenia solium control: Results of a pilot study from northern Lao PDR

被引:24
|
作者
Okello, Anna L. [1 ,2 ,3 ]
Thomas, Lian
Inthavong, Phouth [4 ]
Ash, Amanda [5 ]
Khamlome, Boualam [6 ]
Keokamphet, Chattouphone [4 ]
Newberry, Kim [1 ]
Gauci, Charles G. [7 ]
Gabriel, Sarah [8 ]
Dorny, Pierre [8 ]
Thompson, R. C. Andrew [5 ]
Lightowlers, Marshall W. [7 ]
Allen, John [1 ]
机构
[1] CSIRO, Australian Anim Hlth Lab AAHL Reg Programme, Geelong, Vic, Australia
[2] Univ Edinburgh, Coll Med & Vet Med, Div Pathway Med, Sch Biomed Sci, Chancellors Bldg,49 Little France Crescent, Edinburgh EH16 4SB, Midlothian, Scotland
[3] Univ Edinburgh, Coll Med & Vet Med, Ctr Infect Dis, Sch Biomed Sci, Chancellors Bldg,49 Little France Crescent, Edinburgh EH16 4SB, Midlothian, Scotland
[4] Minist Agr, Dept Livestock & Fisheries, Natl Anim Hlth Lab, Viangchan, Laos
[5] Murdoch Univ, Sch Vet & Life Sci, Perth, WA, Australia
[6] Minist Hlth, Dept Hyg & Prevent, Viangchan, Laos
[7] Univ Melbourne, Fac Vet & Agr Sci, 250 Princes Highway, Werribee, Vic 3030, Australia
[8] Inst Trop Med, Dept Biomed Sci, Natl Str 155, B-2000 Antwerp, Belgium
基金
英国医学研究理事会;
关键词
CYSTICERCOSIS; PEOPLE; HEALTH; FOCUS; PCR;
D O I
10.1016/j.actatropica.2016.03.012
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
Following confirmation that a remote village of approximately 300 inhabitants in northern Lao PDR was hyperendemic for the Neglected Tropical Disease Taenia solium, a pilot human-porcine therapeutic control intervention was implemented between October 2013 and November 2014. Mass drug administration with a three day albendazole 400 mg protocol was offered to all eligible humans in October 2013 and March 2014. At these times, and again in October 2014, eligible village pigs received the anti-cysticercosis TSOL18 vaccination and an oral dose of oxfendazole anthelmintic at 30 mg/kg, both repeated one month later. Community and individual human taeniasis prevalences were estimated via copro-antigen ELISA of volunteered human faecal samples prior to October 2013, and again in January 2015, in order to examine the short term impact of the intervention. (C) 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license.
引用
收藏
页码:185 / 191
页数:7
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