An arachidonic acid generation/export system involved in the regulation of cholesterol transport in mitochondria of steroidogenic cells

被引：27

作者：

Duarte, Alejandra ^{[1
]}

Castillo, Ana Fernanda ^{[1
]}

Castilla, Rocio ^{[1
]}

Maloberti, Paula ^{[1
]}

Paz, Cristina ^{[1
]}

Podesta, Ernesto J. ^{[1
]}

Maciel, Fabiana Cornejo ^{[1
]}

机构：

[1] Univ Buenos Aires, Sch Med, Dept Biochem, Buenos Aires, DF, Argentina

来源：

FEBS LETTERS | 2007年 / 581卷 / 21期

关键词：

arachidonic acid; steroidogenesis; mitochondria; cholesterol transport;

D O I：

10.1016/j.febslet.2007.07.040

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent studies demonstrated the importance of the mitochondrial ATP in the regulation of a novel long-chain fatty acid generation/export system in mitochondria of diabetic rat heart. In steroidogenic systems, mitochondrial ATP and intramitochondrial arachidonic acid (AA) generation are important for steroidogenesis. Here, we report that mitochondrial ATP is necessary for the generation and export of AA, steroid production and steroidogenic acute regulatory protein induction supported by cyclic 3'-5'-adenosine monophosphate in steroidogenic cells. These results demonstrate that ATP depletion affects AA export and provide new evidence of the existence of the fatty acid generation and export system involved in mitochondrial cholesterol transport. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：4023 / 4028

页数：6

共 23 条

[1] Energized, polarized, and actively respiring mitochondria are required for acute Leydig cell steroidogenesis [J].

Allen, John A. ;

Shankara, Tristan ;

Janus, Paul ;

Buck, Steve ;

Diemer, Thorsten ;

Hales, Karen Held ;

Hales, Dale B. .

ENDOCRINOLOGY, 2006, 147 (08) :3924-3935

[2] CHARACTERIZATION OF SEVERAL CLONAL LINES OF CULTURED LEYDIG TUMOR-CELLS - GONADOTROPIN RECEPTORS AND STEROIDOGENIC RESPONSES [J].

ASCOLI, M .

ENDOCRINOLOGY, 1981, 108 (01) :88-95

[3] cAMP increases mitochondrial cholesterol transport through the induction of arachidonic acid release inside this organelle in Leydig cells [J].

Castillo, Ana Fernanda ;

Maciel, Fabiana Cornejo ;

Castilla, Rocio ;

Duarte, Alejandra ;

Maloberti, Paula ;

Paz, Cristina ;

Podesta, Ernesto J. .

FEBS JOURNAL, 2006, 273 (22) :5011-5021

[4]

CRIVELLO JF, 1980, J BIOL CHEM, V255, P8144

[5] Activation of a novel long-chain free fatty acid generation and export system in mitochondria of diabetic rat hearts [J].

Gerber, Lamar K. ;

Aronow, Bruce J. ;

Matlib, Mohammed A. .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2006, 291 (06) :C1198-C1207

[6] Turnover of StAR protein: Roles for the proteasome and mitochondrial proteases [J].

Granot, Zvi ;

Melamed-Book, Naomi ;

Bahat, Assaf ;

Orly, Joseph .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2007, 265 :51-58

[7] A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases [J].

Hunt, MC ;

Yamada, J ;

Maltais, LJ ;

Wright, MW ;

Podesta, EJ ;

Alexson, SEH .

JOURNAL OF LIPID RESEARCH, 2005, 46 (09) :2029-2032

[8] Effects of disruption of the mitochondrial electrochemical gradient on steroidogenesis and the Steroidogenic Acute Regulatory (StAR) protein [J].

King, SR ;

Liu, ZM ;

Soh, J ;

Eimerl, S ;

Orly, J ;

Stocco, DM .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1999, 69 (1-6) :143-154

[9] ATP and a mitochondrial electrochemical gradient are required for functional activity of the steroidogenic acute regulatory (StAR) protein in isolated mitochondria [J].

King, SR ;

Stocco, DM .

ENDOCRINE RESEARCH, 1996, 22 (04) :505-514

[10]

KOWAL J, 1996, ARCH BIOCHEM BIOPHYS, V22, P505

← 1 2 3 →