C-reactive protein: A pentraxin with anti-acetylcholine activity

被引：14

作者：

Nazarov, Peter G.

Krylova, Irina B.

Evdokimova, Natalia R.

Nezhinskaya, Galina I.

Butyugov, Alexander A.

机构：

[1] Inst Expt Med, Lab Gen Immunol, St Petersburg 197376, Russia

[2] Inst Expt Med, SV Anichkov Dept Neuropharm, St Petersburg 197376, Russia

来源：

LIFE SCIENCES | 2007年 / 80卷 / 24-25期

基金：

俄罗斯基础研究基金会;

关键词：

C-reactive protein; acetylcholine; heart rate; arterial pressure; acetylcholinesterase;

D O I：

10.1016/j.lfs.2007.04.031

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Purified C-reactive protein (CRP) diminished effects of acetylcholine (ACh) on the vascular tone and the heart rate of rats in vivo. In vitro CRP inhibited breakdown of ACh by acetylcholinesterase (AChE) while did not interact with AChE itself CRP appears to bind ACh. CRP did not modify the cardiovascular effects of adenosine, another vasorelaxant. The data suggest that there is a new line of cross-talk between the inflammation and cholinergic regulation with CRP acting on endothelium via the ACh-dependent pathway. (c) 2007 Published by Elsevier Inc.

引用

收藏

页码：2337 / 2341

页数：5

相关论文

共 14 条

[1] Effect of C-reactive protein on Fcγ receptor II in cultured bovine endothelial cells [J].

Escribano-Burgos, M ;

López-Farré, A ;

González, MDM ;

Macaya, C ;

García-Méndez, A ;

Mateos-Cáceres, PJ ;

Alonso-Orgaz, S ;

Carrasco, C ;

Rico, LA ;

Cubero, JCP .

CLINICAL SCIENCE, 2005, 108 (01) :85-91

[2] Prognostic value of systemic endothelial dysfunction in patients with acute coronary syndromes - Further evidence for the existence of the "vulnerable" patient [J].

Fichtlscherer, S ;

Breuer, S ;

Zeiher, AM .

CIRCULATION, 2004, 110 (14) :1926-1932

[3] Muscarinic cholinergic regulation of cardiac myocyte ICa-L is absent in mice with targeted disruption of endothelial nitric oxide synthase [J].

Han, XQ ;

Kubota, I ;

Feron, O ;

Opel, DJ ;

Arstall, MA ;

Zhao, YY ;

Huang, P ;

Fishman, MC ;

Michel, T ;

Kelly, RA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (11) :6510-6515

[4] Effects of systemic inflammation on endothelium-dependent vasodilation [J].

Huang, AL ;

Vita, JA .

TRENDS IN CARDIOVASCULAR MEDICINE, 2006, 16 (01) :15-20

[5] HUMAN-LYMPHOCYTES SYNTHESIZE C-REACTIVE PROTEIN [J].

IKUTA, T ;

OKUBO, H ;

ISHIBASHI, H ;

OKUMURA, Y ;

HAYASHIDA, K .

INFLAMMATION, 1986, 10 (03) :223-232

[6] Quantification of O-acetyl, N-acetyl and phosphate groups and determination of the extent of O-acetylation in bacterial vaccine polysaccharides by high-performance anion-exchange chromatography with conductivity detection (HPAEC-CD) [J].

Kao, G ;

Tsai, CM .

VACCINE, 2004, 22 (3-4) :335-344

[7] Extraneuronal cholinergic system in lymphocytes [J].

Kawashima, K ;

Fujii, T .

PHARMACOLOGY & THERAPEUTICS, 2000, 86 (01) :29-48

[8] Expression and function of the non-neuronal cholinergic system in endothelial cells [J].

Kirkpatrick, CJ ;

Bittinger, F ;

Nozadze, K ;

Wessler, I .

LIFE SCIENCES, 2003, 72 (18-19) :2111-2116

[9] FcγRIIB mediates C-reactive protein inhibition of endothelial NO synthase [J].

Mineo, C ;

Gormley, AK ;

Yuhanna, IS ;

Osborne-Lawrence, S ;

Gibson, LL ;

Hahner, L ;

Shohet, RV ;

Black, S ;

Salmon, JE ;

Samols, D ;

Karp, DR ;

Thomas, GD ;

Shaul, PW .

CIRCULATION RESEARCH, 2005, 97 (11) :1124-1131

[10]

Nazarov P.G., 2001, REACTANTS ACUTE PHAS