The Role of Platelets in Diabetic Kidney Disease

被引：16
作者：
Rustiasari, Ukhti Jamil [1 ,2 ,3 ]
Roelofs, Joris J. [1 ,2 ]
机构：
[1] Univ Amsterdam, Amsterdam UMC, Dept Pathol, NL-1105 AZ Amsterdam, Netherlands
[2] Univ Amsterdam, Amsterdam Cardiovasc Sci, NL-1105 AZ Amsterdam, Netherlands
[3] Univ Islam Indonesia, Fac Med, Dept Anat Pathol, Yogyakarta 55584, Indonesia
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 15期
关键词：
diabetes; diabetic kidney disease; diabetic nephropathy; platelets; platelet activation; biomarker; antiplatelet; SOLUBLE CD40 LIGAND; DRUG DILAZEP DIHYDROCHLORIDE; PLASMA BETA-THROMBOGLOBULIN; GLOMERULAR MESANGIAL CELL; FIBROBLAST-GROWTH-FACTOR; CHRONIC-RENAL-FAILURE; BERAPROST SODIUM; ACTIVATING-FACTOR; P-SELECTIN; ADHESION MOLECULES;
D O I：
10.3390/ijms23158270
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Diabetic kidney disease (DKD) is among the most common microvascular complications in patients with diabetes, and it currently accounts for the majority of end-stage kidney disease cases worldwide. The pathogenesis of DKD is complex and multifactorial, including systemic and intra-renal inflammatory and coagulation processes. Activated platelets play a pivotal role in inflammation, coagulation, and fibrosis. Mounting evidence shows that platelets play a role in the pathogenesis and progression of DKD. The potentially beneficial effects of antiplatelet agents in preventing progression of DKD has been studied in animal models and clinical trials. This review summarizes the current knowledge on the role of platelets in DKD, including the potential therapeutic effects of antiplatelet therapies.
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页数：35
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