Thyroid endocrine status and biochemical stress responses in adult male Wistar rats chronically exposed to pristine polystyrene nanoplastics

被引:51
作者
Amereh, Fatemeh [1 ,2 ]
Eslami, Akbar [1 ,2 ]
Fazelipour, Simin [3 ]
Rafiee, Mohammad [1 ,2 ]
Zibaii, Mohammad Ismail [4 ]
Babaei, Mohammad [5 ]
机构
[1] Shahid Beheshti Univ Med Sci, Environm & Occupat Hazards Control Res Ctr, Tehran, Iran
[2] Shahid Beheshti Univ Med Sci, Dept Environm Hlth Engn, Sch Publ Hlth & Safety, Tehran, Iran
[3] Islamic Azad Univ, Dept Anat, Tehran Med Branch, Tehran, Iran
[4] Shahid Beheshti Univ, Laser & Plasma Inst, Tehran, Iran
[5] Bu Ali Sina Univ, Dept Clin Sci, Fac Vet Sci, Hamadan, Hamadan, Iran
关键词
TITANIUM-DIOXIDE NANOPARTICLES; BIOMARKER RESPONSES; WATERBORNE EXPOSURE; PLASTIC DEBRIS; HORMONE; DISRUPTION; MICROPLASTICS; TOXICITY; DEGRADATION; INGESTION;
D O I
10.1039/c9tx00147f
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
Toxicity evaluations of micro- or nano-sized plastics in rodent species commonly employed for toxicity analyses based on which risk assessment for humans could be performed are still largely lacking. Given this knowledge gap, the present work was aimed at determining the potential impact of chronic exposure to polystyrene nanoplastics (PS NPs) on the thyroid endocrine status and biochemical stress in a rat model. Young adult male rats were orally administered with PS NPs (1, 3, 6 and 10 mg kg(-1) day(-1)) for five weeks. Thyroid hormones (THs) l-thyroxine (T4), l-triiodothyronine (T3), l-free triiodothyronine (FT3), and l-free thyroxine (FT4) as well as thyroid stimulating hormone (TSH) serum levels of normal rats and those exposed to PS NPs were compared. Serum levels of high-density lipoprotein (HDL), low-density lipoprotein (LDL), cholesterol, and creatinine, as well as glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) enzymes were also measured. Exposure to PS NPs suppressed the serum levels of T3 and circulating levels of THs, whereas TSH increased significantly. Though exposure to PS NPs did not affect the molar ratios of T3/T4, it induced a slight, but significant, increase in FT3/FT4. In addition, exposure to plastic nanoparticles showed signs of nephrotoxicity induction and kidney injury in exposed organisms as can be inferred from the significantly higher serum levels of creatinine in exposed groups. Our results provide clear evidence of an association between exposure to plastic NPs and thyroid endocrine disruption as well as metabolic deficit, and generate new leads for future research efforts.
引用
收藏
页码:953 / 963
页数:11
相关论文
共 67 条
[1]   Assessment of Thyroid Endocrine System Impairment and Oxidative Stress Mediated by Cobalt Ferrite (CoFe2O4) Nanoparticles in Zebrafish Larvae [J].
Ahmad, Farooq ;
Liu, Xiaoyi ;
Zhou, Ying ;
Yao, Hongzhou ;
Zhao, Fangfang ;
Ling, Zhaoxing ;
Xu, Chao .
ENVIRONMENTAL TOXICOLOGY, 2016, 31 (12) :2068-2080
[2]   Presence of microplastics and nanoplastics in food, with particular focus on seafood [J].
Alexander, Jan ;
Barregard, Lars ;
Bignami, Margherita ;
Ceccatelli, Sandra ;
Cottrill, Bruce ;
Dinovi, Michael ;
Edler, Lutz ;
Grasl-Kraupp, Bettina ;
Hogstrand, Christer ;
Hoogenboom, Laurentius ;
Knutsen, Helle Katrine ;
Nebbia, Carlo Stefano ;
Oswald, Isabelle ;
Petersen, Annette ;
Rogiers, Vera Maria ;
Rose, Martin ;
Roudot, Alain-Claude ;
Schwerdtle, Tanja ;
Vleminckx, Christiane ;
Vollmer, Gunter ;
Wallace, Heather .
EFSA JOURNAL, 2016, 14 (06)
[3]   Serum transaminase elevations as indicators of hepatic injury following the administration of drugs [J].
Amacher, DE .
REGULATORY TOXICOLOGY AND PHARMACOLOGY, 1998, 27 (02) :119-130
[4]   Microplastics in the marine environment [J].
Andrady, Anthony L. .
MARINE POLLUTION BULLETIN, 2011, 62 (08) :1596-1605
[5]   Various Possible Toxicants Involved in Thyroid Dysfunction: A Review [J].
Bajaj, Jagminder K. ;
Salwan, Poonam ;
Salwan, Shalini .
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2016, 10 (01) :FE1-FE3
[6]   Plastic Debris in 29 Great Lakes Tributaries: Relations to Watershed Attributes and Hydrology [J].
Baldwin, Austin K. ;
Corsi, Steven R. ;
Mason, Sherri A. .
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2016, 50 (19) :10377-10385
[7]   Studies on photocatalytic degradation of potystyrene [J].
Bandyopadhyay, A. ;
Chandra Basak, G. .
MATERIALS SCIENCE AND TECHNOLOGY, 2007, 23 (03) :307-314
[8]   Ecotoxicity of engineered nanoparticles to aquatic invertebrates: a brief review and recommendations for future toxicity testing [J].
Baun, A. ;
Hartmann, N. B. ;
Grieger, K. ;
Kusk, K. O. .
ECOTOXICOLOGY, 2008, 17 (05) :387-395
[9]   Nano-sized polystyrene affects feeding, behavior and physiology of brine shrimp Artemia franciscana larvae [J].
Bergami, Elisa ;
Bocci, Elena ;
Vannuccini, Maria Luisa ;
Monopoli, Marco ;
Salvati, Anna ;
Dawson, Kenneth A. ;
Corsi, Ilaria .
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2016, 123 :18-25
[10]   The association between serum TSH concentration and thyroid cancer [J].
Boelaert, Kristien .
ENDOCRINE-RELATED CANCER, 2009, 16 (04) :1065-1072