Emerging technologies in protein interface engineering for biomedical applications

被引：5

作者：

Krohl, Patrick J. ^{[1
]}

Ludwig, Seth D. ^{[1
]}

Spangler, Jamie B. ^{[1
,2
]}

机构：

[1] Johns Hopkins Univ, Dept Chem & Biomol Engn, Baltimore, MD 21218 USA

[2] Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD 21218 USA

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2019年 / 60卷

关键词：

ERYTHROPOIETIN RECEPTOR; COMPUTATIONAL DESIGN; SIGNAL-TRANSDUCTION; PATHWAYS; INTERLEUKIN-2; SPECIFICITY; SELECTIVITY; INHIBITOR; BIOLOGY; IL-2;

D O I：

10.1016/j.copbio.2019.01.017

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Protein interactions communicate critical information from the environment into cells to orchestrate functional responses relevant to health and disease. Whereas the natural repertoire of protein interfaces is finite, biomolecular engineering tools provide access to an unlimited scope of potential interactions that can be custom-designed for affinity, specificity, mechanism, or other properties of interest. This review highlights recent developments in protein interface engineering that offer insight into human physiology to inform the design of new pharmaceuticals, with a particular focus on immunotherapeutics. We cover three innovative and translationally promising approaches: ( I) reprogramming receptor oligomerization to manipulate signaling pathways; (2) computational protein interface design strategies; and (3) engineering bioorthogonal protein interaction networks.

引用

页码：82 / 88

页数：7

共 52 条

[1] The Rosetta All-Atom Energy Function for Macromolecular Modeling and Design [J].

Alford, Rebecca F. ;

Leaver-Fay, Andrew ;

Jeliazkov, Jeliazko R. ;

O'Meara, Matthew J. ;

DiMaio, Frank P. ;

Park, Hahnbeom ;

Shapovalov, Maxim V. ;

Renfrew, P. Douglas ;

Mulligan, Vikram K. ;

Kappel, Kalli ;

Labonte, Jason W. ;

Pacella, Michael S. ;

Bonneau, Richard ;

Bradley, Philip ;

Dunbrack, Roland L., Jr. ;

Das, Rhiju ;

Baker, David ;

Kuhlman, Brian ;

Kortemme, Tanja ;

Gray, Jeffrey J. .

JOURNAL OF CHEMICAL THEORY AND COMPUTATION, 2017, 13 (06) :3031-3048

[2] Prediction of allosteric sites and mediating interactions through bond-to-bond propensities [J].

Amor, B. R. C. ;

Schaub, M. T. ;

Yaliraki, S. N. ;

Barahona, M. .

NATURE COMMUNICATIONS, 2016, 7

[3] Structural plasticity in a remodeled protein-protein interface [J].

Atwell, S ;

Ultsch, M ;

DeVos, AM ;

Wells, JA .

SCIENCE, 1997, 278 (5340) :1125-1128

[4] Engineering Synthetic Signaling Pathways with Programmable dCas9-Based Chimeric Receptors [J].

Baeumler, Toni A. ;

Ahmed, Ahmed Ashour ;

Fulga, Tudor A. .

CELL REPORTS, 2017, 20 (11) :2639-2653

[5] Principles for computational design of binding antibodies [J].

Baran, Dror ;

Pszolla, M. Gabriele ;

Lapidoth, Gideon D. ;

Norn, Christoffer ;

Dym, Orly ;

Unger, Tamar ;

Albeck, Shira ;

Tyka, Michael D. ;

Fleishman, Sarel J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (41) :10900-10905

[6] A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes [J].

Baud, Matthias G. J. ;

Lin-Shiao, Enrique ;

Cardote, Teresa ;

Tallant, Cynthia ;

Pschibul, Annica ;

Chan, Kwok-Ho ;

Zengerle, Michael ;

Garcia, Jordi R. ;

Kwan, Terence T. -L. ;

Ferguson, Fleur M. ;

Ciulli, Alessio .

SCIENCE, 2014, 346 (6209) :638-641

[7] A chemical switch for inhibitor-sensitive alleles of any protein kinase [J].

Bishop, AC ;

Ubersax, JA ;

Petsch, DT ;

Matheos, DP ;

Gray, NS ;

Blethrow, J ;

Shimizu, E ;

Tsien, JZ ;

Schultz, PG ;

Rose, MD ;

Wood, JL ;

Morgan, DO ;

Shokat, KM .

NATURE, 2000, 407 (6802) :395-401

[8] The role of interleukin-2 during homeostasis and activation of the immune system [J].

Boyman, Onur ;

Sprent, Jonathan .

NATURE REVIEWS IMMUNOLOGY, 2012, 12 (03) :180-190

[9] Mechanism of Activation of Protein Kinase JAK2 by the Growth Hormone Receptor [J].

Brooks, Andrew J. ;

Dai, Wei ;

O'Mara, Megan L. ;

Abankwa, Daniel ;

Chhabra, Yash ;

Pelekanos, Rebecca A. ;

Gardon, Olivier ;

Tunny, Kathryn A. ;

Blucher, Kristopher M. ;

Morton, Craig J. ;

Parker, Michael W. ;

Sierecki, Emma ;

Gambin, Yann ;

Gomez, Guillermo A. ;

Alexandrov, Kirill ;

Wilson, Ian A. ;

Doxastakis, Manolis ;

Mark, Alan E. ;

Waters, Michael J. .

SCIENCE, 2014, 344 (6185) :710-+

[10] Computational tools help improve protein stability but with a solubility tradeoff [J].

Broom, Aron ;

Jacobi, Zachary ;

Trainor, Kyle ;

Meiering, Elizabeth M. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 292 (35) :14349-14361

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