Role of MAP kinase in tumor progression and invasion

被引：501
|
作者：
Reddy, KB [1 ]
Nabha, SM [1 ]
Atanaskova, N [1 ]
机构：
[1] Wayne State Univ, Sch Med, Dept Pathol, Detroit, MI 48201 USA
来源：
CANCER AND METASTASIS REVIEWS | 2003年 / 22卷 / 04期
关键词：
apoptosis; invasion; MAPK; metastasis; migration; proteinases;
D O I：
10.1023/A:1023781114568
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathway is a frequent event in tumorigenesis. MAPKs have been implicated in cell migration, proteinase-induction, regulation of apoptosis, and angiogenesis, events that are essential for successful completion of metastasis. In this review, we discuss the potential role that MAPKs play in metastasis by regulating cell migration, proteinase-induction and apoptosis.
引用
收藏
页码：395 / 403
页数：9
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