Role of MAP kinase in tumor progression and invasion

被引：501
|
作者：
Reddy, KB [1 ]
Nabha, SM [1 ]
Atanaskova, N [1 ]
机构：
[1] Wayne State Univ, Sch Med, Dept Pathol, Detroit, MI 48201 USA
来源：
CANCER AND METASTASIS REVIEWS | 2003年 / 22卷 / 04期
关键词：
apoptosis; invasion; MAPK; metastasis; migration; proteinases;
D O I：
10.1023/A:1023781114568
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathway is a frequent event in tumorigenesis. MAPKs have been implicated in cell migration, proteinase-induction, regulation of apoptosis, and angiogenesis, events that are essential for successful completion of metastasis. In this review, we discuss the potential role that MAPKs play in metastasis by regulating cell migration, proteinase-induction and apoptosis.
引用
收藏
页码：395 / 403
页数：9
相关论文
共 50 条
  • [31] Role of the α3β1 and α6β4 integrins in tumor invasion
    Giannelli, G
    Astigiano, S
    Antonaci, S
    Morini, M
    Barbieri, O
    Noonan, DM
    Albini, A
    CLINICAL & EXPERIMENTAL METASTASIS, 2002, 19 (03) : 217 - 223
  • [32] The role of tumor microenvironment in collective tumor cell invasion
    Wu, Jia-shun
    Sheng, Su-rui
    Liang, Xin-hua
    Tang, Ya-ling
    FUTURE ONCOLOGY, 2017, 13 (11) : 991 - 1002
  • [33] The role of RhoC in malignant tumor invasion, metastasis and targeted therapy
    Guan, Xue
    Chen, Shuo
    Zhao, Yang
    HISTOLOGY AND HISTOPATHOLOGY, 2018, 33 (03) : 255 - 260
  • [34] THE ROLE OF MATRIX METALLOPROTEASES AND THEIR INHIBITORS IN TUMOR INVASION, METASTASIS AND ANGIOGENESIS
    RAY, JM
    STETLERSTEVENSON, WG
    EUROPEAN RESPIRATORY JOURNAL, 1994, 7 (11) : 2062 - 2072
  • [35] Oncogenic Ras and its role in tumor cell invasion and metastasis
    Campbell, PM
    Der, CJ
    SEMINARS IN CANCER BIOLOGY, 2004, 14 (02) : 105 - 114
  • [36] Role of the α3β1 and α6β4 integrins in tumor invasion
    Gianluigi Giannelli
    Simonetta Astigiano
    Salvatore Antonaci
    Monica Morini
    Ottavia Barbieri
    Douglas M. Noonan
    Adriana Albini
    Clinical & Experimental Metastasis, 2002, 19 : 217 - 223
  • [37] Role of mTOR Signaling in Tumor Cell Motility, Invasion and Metastasis
    Zhou, Hongyu
    Huang, Shile
    CURRENT PROTEIN & PEPTIDE SCIENCE, 2011, 12 (01) : 30 - 42
  • [38] ROLE OF PROTEINASES AND THEIR INHIBITORS IN TUMOR INVASION
    OGLOBLINA, OG
    AREFEVA, TI
    BIOCHEMISTRY-MOSCOW, 1994, 59 (03) : 241 - 247
  • [39] The role of lncRNA ANRIL in the progression of hepatocellular carcinoma
    Han, Weijie
    Wang, Qiuhong
    Zheng, Liansheng
    Hong, Hong
    Yan, Boshi
    Ma, Yongqiang
    Li, Xiaolong
    Zhou, Dinghua
    JOURNAL OF PHARMACY AND PHARMACOLOGY, 2021, 73 (08) : 1033 - 1038
  • [40] The role of proto-oncogene Fra-1 in remodeling the tumor microenvironment in support of breast tumor cell invasion and progression
    Luo, Y. P.
    Zhou, H.
    Krueger, J.
    Kaplan, C.
    Liao, D.
    Markowitz, D.
    Liu, C.
    Chen, T.
    Chuang, T-H
    Xiang, R.
    Reisfeld, R. A.
    ONCOGENE, 2010, 29 (05) : 662 - 673
12345