Relationship between serum IL-7 concentrations and lymphopenia upon different levels of HIV immune control

被引：16
作者：
Fluur, Caroline [1 ]
Rethi, Bence
Thang, Pham Hong
Vivar, Nancy
Mowafi, Frida
Lopalco, Lucia
Foppa, Caterina Uberti
Karlsson, Anders
Tambussi, Giuseppe
Chiodi, Francesca
机构：
[1] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden
[2] Natl Inst Hyg & Epidemiol, HIV AIDS Dept, Hanoi, Vietnam
[3] Ist Sci San Raffaele, Infect Dis Clin, I-20132 Milan, Italy
[4] Karolinska Univ Hosp, Dept Infect Dis, Stockholm, Sweden
来源：
AIDS | 2007年 / 21卷 / 08期
关键词：
D O I：
10.1097/QAD.0b013e32810c8caa
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Serum IL-7 levels correlate with T-cell depletion in HIV-infected individuals. In some patients, we observed that serum IL-7 decreases upon progression to AIDS, suggesting a role for IL-7 in T-cell maintenance in sporadic cases. Interestingly, IL-7 levels were significantly lower in stable longterm non-progressors (LTNP) than in patients who lost the LTNP status in a 3-year follow-up (P < 0.001), indicating that the serum IL-7 concentration might be a valuable marker for maintenance of the LTNP state.
引用
收藏
页码：1048 / 1050
页数：3
相关论文
共 15 条
  • [1] Boulassel MR, 2004, HIV CLIN TRIALS, V5, P357
  • [2] Chêne L, 1999, J VIROL, V73, P7533
  • [3] A potential role for interleukin-7 in T-cell homeostasis
    Fry, TJ
    Connick, E
    Falloon, J
    Lederman, MM
    Liewehr, DJ
    Spritzler, J
    Steinberg, SM
    Wood, LV
    Yarchoan, R
    Zuckerman, J
    Landay, A
    Mackall, CL
    [J]. BLOOD, 2001, 97 (10) : 2983 - 2990
  • [4] The many faces of IL-7: From lymphopoiesis to peripheral T cell maintenance
    Fry, TJ
    Mackall, CL
    [J]. JOURNAL OF IMMUNOLOGY, 2005, 174 (11) : 6571 - 6576
  • [5] Interleukin-7: master regulator of peripheral T-cell homeostasis?
    Fry, TJ
    Mackall, CL
    [J]. TRENDS IN IMMUNOLOGY, 2001, 22 (10) : 564 - 571
  • [6] Interleukin-7: physiological roles and mechanisms of action
    Hofmeister, R
    Khaled, AR
    Benbernou, N
    Rajnavolgyi, E
    Muegge, K
    Durum, SK
    [J]. CYTOKINE & GROWTH FACTOR REVIEWS, 1999, 10 (01) : 41 - 60
  • [7] Lymphocide: Cytokines and the control of lymphoid homeostasis
    Khaled, AR
    Durum, SK
    [J]. NATURE REVIEWS IMMUNOLOGY, 2002, 2 (11) : 817 - 830
  • [8] Interleukin-7 in plasma correlates with CD4 T-cell depletion and may be associated with emergence of syncytium-inducing variants in human immunodeficiency virus type 1-positive individuals
    Llano, A
    Barretina, J
    Gutiérrez, A
    Blanco, J
    Cabrera, C
    Clotet, B
    Esté, JA
    [J]. JOURNAL OF VIROLOGY, 2001, 75 (21) : 10319 - 10325
  • [9] Mastroianni C M, 2001, HIV Clin Trials, V2, P108
  • [10] Increased production of IL-7 accompanies HIV-l-mediated T-cell depletion: implications for T-cell homeostasis
    Napolitano, LA
    Grant, RM
    Deeks, SG
    Schmidt, D
    De Rosa, SC
    Herzenberg, LA
    Herndier, BG
    Andersson, J
    McCune, JM
    [J]. NATURE MEDICINE, 2001, 7 (01) : 73 - 79
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