Association between NME8 Locus Polymorphism and Cognitive Decline, Cerebrospinal Fluid and Neuroimaging Biomarkers in Alzheimer's Disease

被引:15
作者
Liu, Ying [1 ]
Yu, Jin-Tai [1 ,2 ,3 ]
Wang, Hui-Fu [3 ]
Hao, Xiao-Ke [4 ]
Yang, Yu-Fen [5 ]
Jiang, Teng [6 ]
Zhu, Xi-Chen [3 ]
Cao, Lei [3 ]
Zhang, Dao-Qiang [4 ]
Tan, Lan [1 ,2 ,3 ]
机构
[1] Dalian Med Univ, Qingdao Municipal Hosp, Dept Neurol, Qingdao, Peoples R China
[2] Qingdao Univ, Qingdao Municipal Hosp, Sch Med, Dept Neurol, Qingdao, Peoples R China
[3] Nanjing Med Univ, Qingdao Municipal Hosp, Dept Neurol, Nanjing, Jiangsu, Peoples R China
[4] Nanjing Univ Aeronaut & Astronaut, Dept Comp Sci & Engn, Nanjing, Jiangsu, Peoples R China
[5] Air Beijing Dongjiao Lane Community Hlth, Beijing, Peoples R China
[6] Nanjing Med Univ, Nanjing Hosp 1, Dept Neurol, Nanjing, Jiangsu, Peoples R China
来源
PLOS ONE | 2014年 / 9卷 / 12期
基金
中国国家自然科学基金; 美国国家卫生研究院;
关键词
NUCLEOSIDE DIPHOSPHATE KINASE; LEWY BODIES; BRAIN; EXPRESSION; GENE; SUSCEPTIBILITY; EPIDEMIOLOGY; DEMENTIA; VOLUME; NM23;
D O I
10.1371/journal.pone.0114777
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Recently, a large meta-analysis of five genome wide association studies (GWAS) identified a novel locus (rs2718058) adjacent to NME8 that played a preventive role in Alzheimer's disease (AD). However, this link between the single nucleotide polymorphism (SNP) rs2718058 and the pathology of AD have not been mentioned yet. Therefore, this study assessed the strength of association between the NME8 rs2718058 genotypes and AD-related measures including the cerebrospinal fluid (CSF) amyloid beta, tau, P-tau concentrations, neuroimaging biomarkers and cognitive performance, in a large cohort from Alzheimer's Disease Neuroimaging Initiative (ADNI) database. We used information of a total of 719 individuals, including 211 normal cognition (NC), 346 mild cognitive impairment (MCI) and 162 AD. Although we didn't observe a positive relationship between rs2718058 and AD, it was significantly associated with several AD related endophenotypes. Among the normal cognitively normal participants, the minor allele G carriers showed significantly associated with higher CDRSB score than A allele carriers (P=0.021). Occipital gyrus atrophy were significantly associated with NME8 genotype status (P=0.002), with A allele carriers has more atrophy than the minor allele G carriers in AD patients; lateral ventricle (both right and left) cerebral metabolic rate for glucose (CMRgl) were significantly associated with NME8 genotype (P<0.05), with GA genotype had higher metabolism than GG and AA genotypes in MCI group; the atrophic right hippocampus in 18 months is significantly different between the three group, with GG and AA genotypes had more hippocampus atrophy than GA genotypes in the whole group. Together, our results are consistent with the direction of previous research, suggesting that NME8 rs2718058 appears to play a role in lowering the brain neurodegeneration.
引用
收藏
页数:13
相关论文
共 29 条
[1]   Measuring Memory in Large Group Settings Using a Continuous Recognition Test [J].
Ashford, J. Wesson ;
Gere, Emily ;
Bayley, Peter J. .
JOURNAL OF ALZHEIMERS DISEASE, 2011, 27 (04) :885-895
[2]   Imaging the Alzheimer Brain [J].
Ashford, J. Wesson ;
Salehi, Ahmad ;
Furst, Ansgar ;
Bayley, Peter ;
Frisoni, Giovanni B. ;
Jack, Clifford R., Jr. ;
Sabri, Osama ;
Adamson, Maheen M. ;
Coburn, Kerry L. ;
Olichney, John ;
Schuff, Norbert ;
Spielman, Daniel ;
Edland, Steven D. ;
Black, Sandra ;
Rosen, Allyson ;
Kennedy, David ;
Weiner, Michael ;
Perry, George .
JOURNAL OF ALZHEIMERS DISEASE, 2011, 26 :1-27
[3]   Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis [J].
Baranzini, Sergio E. ;
Wang, Joanne ;
Gibson, Rachel A. ;
Galwey, Nicholas ;
Naegelin, Yvonne ;
Barkhof, Frederik ;
Radue, Ernst-Wilhelm ;
Lindberg, Raija L. P. ;
Uitdehaag, Bernard M. G. ;
Johnson, Michael R. ;
Angelakopoulou, Aspasia ;
Hall, Leslie ;
Richardson, Jill C. ;
Prinjha, Rab K. ;
Gass, Achim ;
Geurts, Jeroen J. G. ;
Kragt, Jolijn ;
Sombekke, Madeleine ;
Vrenken, Hugo ;
Qualley, Pamela ;
Lincoln, Robin R. ;
Gomez, Refujia ;
Caillier, Stacy J. ;
George, Michaela F. ;
Mousavi, Hourieh ;
Guerrero, Rosa ;
Okuda, Darin T. ;
Cree, Bruce A. C. ;
Green, Ari J. ;
Waubant, Emmanuelle ;
Goodin, Douglas S. ;
Pelletier, Daniel ;
Matthews, Paul M. ;
Hauser, Stephen L. ;
Kappos, Ludwig ;
Polman, Chris H. ;
Oksenberg, Jorge R. .
HUMAN MOLECULAR GENETICS, 2009, 18 (04) :767-778
[4]   Genetic Variation and Neuroimaging Measures in Alzheimer Disease [J].
Biffi, Alessandro ;
Anderson, Christopher D. ;
Desikan, Rahul S. ;
Sabuncu, Mert ;
Cortellini, Lynelle ;
Schmansky, Nick ;
Salat, David ;
Rosand, Jonathan .
ARCHIVES OF NEUROLOGY, 2010, 67 (06) :677-685
[5]   EPIDEMIOLOGY OF ALZHEIMERS-DISEASE [J].
BRETELER, MMB ;
CLAUS, JJ ;
VANDUIJN, CM ;
LAUNER, LJ ;
HOFMAN, A .
EPIDEMIOLOGIC REVIEWS, 1992, 14 :59-82
[6]   NM23 GENE-EXPRESSION CORRELATES WITH CELL-GROWTH RATE AND S-PHASE [J].
CALIGO, MA ;
CIPOLLINI, G ;
FIORE, L ;
CALVO, S ;
BASOLO, F ;
COLLECCHI, P ;
CIARDIELLO, F ;
PEPE, S ;
PETRINI, M ;
BEVILACQUA, G .
INTERNATIONAL JOURNAL OF CANCER, 1995, 60 (06) :837-842
[7]   GENE DOSE OF APOLIPOPROTEIN-E TYPE-4 ALLELE AND THE RISK OF ALZHEIMERS-DISEASE IN LATE-ONSET FAMILIES [J].
CORDER, EH ;
SAUNDERS, AM ;
STRITTMATTER, WJ ;
SCHMECHEL, DE ;
GASKELL, PC ;
SMALL, GW ;
ROSES, AD ;
HAINES, JL ;
PERICAKVANCE, MA .
SCIENCE, 1993, 261 (5123) :921-923
[8]   A common variant in combination with a nonsense mutation in a member of the thioredoxin family causes primary ciliary dyskinesia [J].
Duriez, Benedicte ;
Duquesnoy, Philippe ;
Escudier, Estelle ;
Bridoux, Anne-Marie ;
Escalier, Denise ;
Rayet, Isabelle ;
Marcos, Elisabeth ;
Vojtek, Anne-Marie ;
Bercher, Jean-Francois ;
Amselem, Serge .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (09) :3336-3341
[9]   The FAS gene, brain volume, and disease progression in Alzheimer's disease [J].
Erten-Lyons, Deniz ;
Jacobson, Anne ;
Kramer, Patricia ;
Grupe, Andrew ;
Kaye, Jeffrey .
ALZHEIMERS & DEMENTIA, 2010, 6 (02) :118-124
[10]  
Jiang T, 2013, CURR ALZHEIMER RES, V10, P852