Antiangiogenic versus cytotoxic activity in analogues of aeroplysinin-1

被引：36
作者：
Cordoba, Ruben [1 ]
Salvador Tormo, Nelida
Fernandez Medarde, Antonio
Plumet, Joaquin
机构：
[1] Univ Complutense, Fac Quim, Dept Quim Organ, E-28040 Madrid, Spain
[2] Inst Biomar SA, Leon 24231, Spain
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2007年 / 15卷 / 15期
关键词：
antiangiogenic compounds; cytotoxicity; aeroplysinin-1; spiroepoxycyclohexadienones;
D O I：
10.1016/j.bmc.2007.05.011
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A series of analogues of the potentially angiogenic inhibitor aeroplysinin-l 1 were synthesized and their in vitro antiangiogenic and cytotoxic activities evaluated. In the case of epoxy ketone 6 and azlactone 36 the relationship sprouting inhibition assayl cytotoxicity in BAE cells was enhanced by one order and two orders of magnitude, respectively, with respect to the reference. These results imply more specific antiangiogenic properties for the synthesized derivatives. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5300 / 5315
页数：16
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