Ulcerative colitis: focus on colonic mucosal resistance

被引：1
|
作者：
Livzan, M. A. [1 ,2 ]
Bicbavova, G. R. [1 ,3 ]
Romanyuk, A. E. [1 ,4 ]
机构：
[1] Omsk State Med Univ OSMU, 12 Lenina Str, Omsk 644099, Russia
[2] OSMU, Dept Intermediate Level Therapy & Gastroenterol, Omsk, Russia
[3] OSMU, Dept Adv Level Therapy & Endocrinol, Omsk, Russia
[4] OSMU, Dept Gen Med, Omsk, Russia
来源：
BYULLETEN SIBIRSKOY MEDITSINY | 2022年 / 21卷 / 01期
关键词：
ulcerative colitis; microbiota; epithelial barrier; mucin; tight junction proteins; epithelial cells; immunoglobulins A; INFLAMMATORY-BOWEL-DISEASE; TIGHT JUNCTION; GUT MICROBIOTA; TREFOIL FACTORS; INTESTINAL MUCUS; MUCIN; BARRIER; EXPRESSION; CLAUDIN-2; PROTEIN;
D O I：
10.20538/1682-0363-2022-1-121-132
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In recent decades, following cooperation between scientists in various specialties, new unique data on the pathogenesis of ulcerative colitis have been obtained. The role of an impaired immune response to antigens of gut microbiota in genetically predisposed individuals under the effect of certain environmental factors was proven. Assessing the interaction between the colonic mucosa and gut microbiota will help to understand the mechanisms of ulcerative colitis and develop new treatment strategies for the disease. This review presents modern views on the pathogenesis of ulcerative colitis with a focus on the imbalance between local protective and aggressive factors of the gastric and intestinal mucosa. The structure and role of the epithelial barrier both under normal conditions and in ulcerative colitis are considered in detail. The aim of this review was to summarize the data on resistance of the colonic mucosa and its damage in ulcerative colitis.
引用
收藏
页码：121 / 132
页数：12
相关论文
共 50 条
  • [41] Cross Talk between Gut Microbiota and Intestinal Mucosal Immunity in the Development of Ulcerative Colitis
    Zou, Junfeng
    Liu, Chen
    Jiang, Shu
    Qian, Dawei
    Duan, Jinao
    INFECTION AND IMMUNITY, 2021, 89 (09)
  • [42] Mucosal bacteria in ulcerative colitis
    Macfarlane, S
    Furrie, E
    Kennedy, A
    Cummings, JH
    Macfarlane, GT
    BRITISH JOURNAL OF NUTRITION, 2005, 93 : S67 - S72
  • [43] The Correlation Between Fecal Amino Acids, Colonic Mucosal Taste Receptors, and Clinical Features and Indicators of Ulcerative Colitis: A Multicenter Exploratory Study
    Liu, Yixin
    Sha, Sumei
    Ran, Qiuju
    Shi, Haitao
    Ma, Juan
    Qin, Bin
    Li, Yingchao
    Wang, Ning
    Liu, Xin
    Wang, Jinhai
    Li, Lu
    Liu, Na
    Quan, Xiaojing
    INFLAMMATORY BOWEL DISEASES, 2025,
  • [44] Reduced hydrophobicity of the colonic mucosal surface in ulcerative colitis as a hint at a physicochemical barrier defect
    Annika Braun
    Ulrike Schönfeld
    Thilo Welsch
    Martina Kadmon
    Benjamin Funke
    Daniel Gotthardt
    Alexandra Zahn
    Frank Autschbach
    Peter Kienle
    Michael Zharnikov
    Michael Grunze
    Wolfgang Stremmel
    Robert Ehehalt
    International Journal of Colorectal Disease, 2011, 26 : 989 - 998
  • [45] Reduced hydrophobicity of the colonic mucosal surface in ulcerative colitis as a hint at a physicochemical barrier defect
    Braun, Annika
    Schoenfeld, Ulrike
    Welsch, Thilo
    Kadmon, Martina
    Funke, Benjamin
    Gotthardt, Daniel
    Zahn, Alexandra
    Autschbach, Frank
    Kienle, Peter
    Zharnikov, Michael
    Grunze, Michael
    Stremmel, Wolfgang
    Ehehalt, Robert
    INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 2011, 26 (08) : 989 - 998
  • [46] Fecal calprotectin and ulcerative colitis endoscopic activity index as indicators of mucosal healing in ulcerative colitis
    Tarang Taghvaei
    Iradj Maleki
    Farshad Nagshvar
    Hafez Fakheri
    Vahid Hosseini
    Seyed Mohammad Valizadeh
    Hassan Neishaboori
    Internal and Emergency Medicine, 2015, 10 : 321 - 328
  • [47] Fecal calprotectin and ulcerative colitis endoscopic activity index as indicators of mucosal healing in ulcerative colitis
    Taghvaei, Tarang
    Maleki, Iradj
    Nagshvar, Farshad
    Fakheri, Hafez
    Hosseini, Vahid
    Valizadeh, Seyed Mohammad
    Neishaboori, Hassan
    INTERNAL AND EMERGENCY MEDICINE, 2015, 10 (03) : 321 - 328
  • [48] Involvement of nitrergic neurons in colonic motility in a rat model of ulcerative colitis
    Li, Yan-Rong
    Li, Yan
    Jin, Yuan
    Xu, Mang
    Fan, Hong-Wei
    Zhang, Qian
    Tan, Guo-He
    Chen, Jing
    Li, Yun-Qing
    WORLD JOURNAL OF GASTROENTEROLOGY, 2022, 28 (29) : 3854 - 3868
  • [49] Rapid migration of thymic emigrants to the colonic mucosa in ulcerative colitis patients
    Elgbratt, K.
    Kurlberg, G.
    Hahn-Zohric, M.
    Hornquist, E. Hultgren
    CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2010, 162 (02): : 325 - 336
  • [50] Fibrotic and Vascular Remodelling of Colonic Wall in Patients with Active Ulcerative Colitis
    Ippolito, Chiara
    Colucci, Rocchina
    Segnani, Cristina
    Errede, Mariella
    Girolamo, Francesco
    Virgintino, Daniela
    Dolfi, Amelio
    Tirotta, Erika
    Buccianti, Piero
    Di Candio, Giulio
    Campani, Daniela
    Castagna, Maura
    Bassotti, Gabrio
    Villanacci, Vincenzo
    Blandizzi, Corrado
    Bernardini, Nunzia
    JOURNAL OF CROHNS & COLITIS, 2016, 10 (10): : 1194 - 1204
12345