Monitoring fast chemical processes by reaction-interrupted excitation transfer (ExTra) NMR spectroscopy

被引：11

作者：

Wagner, Gabriel E. ^{[1
]}

Tassoti, Sebastian ^{[2
]}

Glanzer, Simon ^{[2
]}

Stadler, Eduard ^{[3
]}

Herges, Rainer ^{[4
]}

Gescheidt, Georg ^{[3
]}

Zangger, Klaus ^{[2
]}

机构：

[1] Med Univ Graz, Inst Hyg Microbiol & Environm Med, Neue Stiftingtalstr 6, A-8010 Graz, Austria

[2] Karl Franzens Univ Graz, Inst Chem Organ & Bioorgan Chem, Heinrichstr 28, A-8010 Graz, Austria

[3] Graz Univ Technol, Inst Phys & Theoret Chem, Stremayrgasse 9, A-8010 Graz, Austria

[4] Univ Kiel, Otto Diels Inst Organ Chem, Otto Hahn Pl 4, DE-24118 Kiel, Germany

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 83期

关键词：

RAPID-INJECTION NMR; TIME-RESOLVED CIDNP; 2-DIMENSIONAL NMR; PHOTO-CIDNP; PROTEIN; INTERMEDIATE; MECHANISM; KINETICS; STATES;

D O I：

10.1039/c9cc06427c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

NMR spectroscopy is generally used to investigate molecules under equilibrium conditions. Despite recent technological and methodogical developments to study on-going reactions, tracing the fate of individual atoms during an irreversible chemical reaction is still a challenging and elaborate task. Reaction-interrupted excitation transfer (ExTra) NMR provides a selective tracking of resonances from atoms, which undergo chemical conversion. We show that reactions triggered either by rapid mixing or by photo-excitation can be conveniently followed at a sub-second time scale using standard NMR equipment. In ExTra NMR we use the selectively inverted magnetization of a selected atom to follow its conversion in the course of a fast chemical reaction. The chemical reaction has to be started within the relaxation period of an initial inverting 180 degrees pulse. The presented protocol provides a generally applicable NMR method for reaction monitoring.

引用

页码：12575 / 12578

页数：4

共 43 条

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