The Parkinson Disease Mitochondrial Hypothesis: Where Are We at?

被引：114

作者：

Franco-Iborra, Sandra ^{[1
]}

Vila, Miquel ^{[1
,2
,3
]}

Perier, Celine ^{[1
]}

机构：

[1] Vall Hebron Res Inst CIBERNED, Barcelona, Spain

[2] Catalan Inst Res & Adv Studies ICREA, Barcelona, Spain

[3] Autonomous Univ Barcelona, Dept Biochem & Mol Biol, Barcelona, Spain

来源：

NEUROSCIENTIST | 2016年 / 22卷 / 03期

关键词：

complex I; apoptosis; fusion/fission; mtDNA; mitochondria-associated endoplasmic reticulum membranes; COMPLEX-I DEFICIENCY; SUBSTANTIA-NIGRA NEURONS; ALPHA-SYNUCLEIN; ENDOPLASMIC-RETICULUM; CELL-DEATH; DOPAMINERGIC-NEURONS; DNA MUTATIONS; OXIDATIVE STRESS; CYTOCHROME-C; PROTEIN DJ-1;

D O I：

10.1177/1073858415574600

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Parkinson's disease is a common, adult-onset neurodegenerative disorder whose pathogenesis is still under intense investigation. Substantial evidence from postmortem human brain tissue, genetic- and toxin-induced animal and cellular models indicates that mitochondrial dysfunction plays a central role in the pathophysiology of the disease. This review discusses our current understanding of Parkinson's disease-related mitochondrial dysfunction, including bioenergetic defects, mitochondrial DNA alterations, altered mitochondrial dynamics, activation of mitochondrial-dependent programmed cell death, and perturbations in mitochondrial tethering to the endoplasmic reticulum. Whether a primary or secondary event, mitochondrial dysfunction holds promise as a potential therapeutic target to halt the progression of neurodegeneration in Parkinson's disease.

引用

页码：266 / 277

页数：12

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