A Comparison of Micro-CT and Dental CT in Assessing Cortical Bone Morphology and Trabecular Bone Microarchitecture

被引：35

作者：

Hsu, Jui-Ting ^{[1
]}

Chen, Ying-Ju ^{[2
]}

Ho, Jung-Ting ^{[1
]}

Huang, Heng-Li ^{[1
]}

Wang, Shun-Ping ^{[3
]}

Cheng, Fu-Chou ^{[2
]}

Wu, Jay ^{[4
]}

Tsai, Ming-Tzu ^{[5
]}

机构：

[1] China Med Univ, Sch Dent, Coll Med, Taichung, Taiwan

[2] Taichung Vet Gen Hosp, Dept Med Res, Stem Cell Med Res Ctr, Taichung, Taiwan

[3] Taichung Vet Gen Hosp, Dept Orthopaed, Taichung, Taiwan

[4] China Med Univ, Dept Biomed Imaging & Radiol Sci, Taichung, Taiwan

[5] Hungkuang Univ, Dept Biomed Engn, Taichung, Taiwan

来源：

PLOS ONE | 2014年 / 9卷 / 09期

关键词：

BEAM COMPUTED-TOMOGRAPHY; STRENGTH; DENSITY; VALUES; BODY;

D O I：

10.1371/journal.pone.0107545

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Objective: The objective of this study was to evaluate the relationship between the trabecular bone microarchitecture and cortical bone morphology by using micro-computed tomography (micro-CT) and dental cone-beam computed tomography (dental CT). Materials and Methods: Sixteen femurs and eight fifth lumbar vertebrae were collected from eight male Sprague Dawley rats. Four trabecular bone microarchitecture parameters related to the fifth lumbar vertebral body (percent bone volume [BV/TV], trabecular thickness [TbTh], trabecular separation [TbSp], and trabecular number [TbN]) were calculated using micro-CT. In addition, the volumetric cancellous bone grayscale value (vCanGrayscale) of the fifth lumbar vertebral body was measured using dental CT. Furthermore, four cortical bone morphology parameters of the femoral diaphysis (total crosssectional area [TtAr], cortical area [CtAr], cortical bone area fraction [CtAr/TtAr], and cortical thickness [CtTh]) were calculated using both micro-CT and dental CT. Pearson analysis was conducted to calculate the correlation coefficients (r) of the microCT and dental CT measurements. Paired-sample t tests were used to compare the differences between the measurements of the four cortical bone morphology parameters obtained using micro-CT and dental CT. Results: High correlations between the vCanGrayscale measured using dental CT and the trabecular bone microarchitecture parameters (BV/TV [r = 0.84] and TbTh [r = 0.84]) measured using micro-CT were observed. The absolute value of the four cortical bone morphology parameters may be different between the dental CT and micro-CT approaches. However, high correlations (r ranged from 0.71 to 0.90) among these four cortical bone morphology parameters measured using the two approaches were obtained. Conclusion: We observed high correlations between the vCanGrayscale measured using dental CT and the trabecular bone microarchitecture parameters (BV/TV and TbTh) measured using micro-CT, in addition to high correlations between the cortical bone morphology measured using micro-CT and dental CT. Further experiments are necessary to validate the use of dental CT on human bone.

引用

页数：8

共 34 条

[1] Conventional Multi-Slice Computed Tomography (CT) and Cone-Beam CT (CBCT) for Computer-Assisted Implant Placement. Part I: Relationship of Radiographic Gray Density and Implant Stability [J].