Facts and fictions of HCV and comorbidities: Steatosis, diabetes mellitus, and cardiovascular diseases

被引：142

作者：

Negro, Francesco ^{[1
,2
,3
]}

机构：

[1] Univ Hosp Geneva, Div Gastroenterol, CH-1211 Geneva 4, Switzerland

[2] Univ Hosp Geneva, Div Hepatol, CH-1211 Geneva 4, Switzerland

[3] Univ Hosp Geneva, Div Clin Pathol, CH-1211 Geneva 4, Switzerland

来源：

JOURNAL OF HEPATOLOGY | 2014年 / 61卷

基金：

瑞士国家科学基金会;

关键词：

Hepatitis C virus; Steatosis; Insulin resistance; Diabetes; Coronary artery disease; Atherosclerosis; Stroke; HEPATITIS-C VIRUS; SUSTAINED VIROLOGICAL RESPONSE; HIV-INFECTED PATIENTS; POSTLOAD INSULIN-RESISTANCE; ALPHA-2A PLUS RIBAVIRIN; POPULATION-BASED COHORT; FATTY LIVER-DISEASE; HEPATOCELLULAR-CARCINOMA; NONALCOHOLIC STEATOHEPATITIS; GENOTYPE;

D O I：

10.1016/j.jhep.2014.08.003

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The hepatitis C virus (HCV) is a major cause of chronic hepatitis, cirrhosis and hepatocellular carcinoma worldwide. A significant portion of the morbidity and mortality associated with HCV is a consequence of numerous HCV-associated comorbidities. Type 2 diabetes and atherosclerosis, two known complications of the metabolic syndrome, are noteworthy, because HCV has been suggested to play a role in their pathogenesis. In addition, HCV also causes steatosis, which may increase the risk of cardiovascular events. This review summarizes the evidence supporting the association between HCV and steatosis, insulin resistance/type 2 diabetes and cardiovascular morbidity and mortality. Their diagnostic, prognostic and management aspects are discussed. (C) 2014 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

引用

页码：S69 / S78

页数：10

共 132 条

[1] Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity [J].

Adinolfi, LE ;

Gambardella, M ;

Andreana, A ;

Tripodi, MF ;

Utili, R ;

Ruggiero, G .

HEPATOLOGY, 2001, 33 (06) :1358-1364

[2] Chronic HCV infection is a risk of atherosclerosis. Role of HCV and HCV-related steatosis [J].

Adinolfi, Luigi E. ;

Restivo, Luciano ;

Zampino, Rosa ;

Guerrera, Barbara ;

Lonardo, Amedeo ;

Ruggiero, Laura ;

Riello, Francesco ;

Loria, Paola ;

Florio, Anna .

ATHEROSCLEROSIS, 2012, 221 (02) :496-502

[3] Sustained virological response prevents the development of insulin resistance in patients with chronic hepatitis C [J].

Aghemo, Alessio ;

Prati, Gian Maria ;

Rumi, Maria Grazia ;

Soffredini, Roberta ;

D'Ambrosio, Roberta ;

Orsi, Emanuela ;

De Nicola, Stella ;

Degasperi, Elisabetta ;

Grancini, Valeria ;

Colombo, Massimo .

HEPATOLOGY, 2012, 56 (05) :1681-1687

[4] Hepatitis C Infection is Associated With Increased Coronary Artery Atherosclerosis Defined by Modified Reardon Severity Score System [J].

Alyan, Omer ;

Kacmaz, Fehmi ;

Ozdemir, Ozean ;

Deveci, Bulent ;

Astan, Ramazan ;

Celebi, Aksuyek Savas ;

Ilkay, Erdogan .

CIRCULATION JOURNAL, 2008, 72 (12) :1960-1965

[5] Causes of death after diagnosis of hepatitis B or hepatitis C infection: a large community-based linkage study [J].

Amin, Janaki ;

Law, Matthew G. ;

Bartlett, Mark ;

Kaldor, John M. ;

Dore, Gregory J. .

LANCET, 2006, 368 (9539) :938-945

[6] Effect of type 2 diabetes on risk for malignancies includes hepatocellular carcinoma in chronic hepatitis C [J].

Arase, Yasuji ;

Kobayashi, Mariko ;

Suzuki, Fumitaka ;

Suzuki, Yoshiyuki ;

Kawamura, Yusuke ;

Akuta, Norio ;

Kobayashi, Masahiro ;

Sezaki, Hitomi ;

Saito, Satoshi ;

Hosaka, Tetsuya ;

Ikeda, Kenji ;

Kumada, Hiromitsu ;

Kobayashi, Tetsuro .

HEPATOLOGY, 2013, 57 (03) :964-973

[7] Sustained Virological Response Reduces Incidence of Onset of Type 2 Diabetes in Chronic Hepatitis C [J].

Arase, Yasuji ;

Suzuki, Fumitaka ;

Suzuki, Yoshiyuki ;

Akuta, Norio ;

Kobayashi, Masahiro ;

Kawamura, Yusuke ;

Yatsuji, Hiromi ;

Sezaki, Hitomi ;

Ilosaka, Tetsuya ;

Hirakawa, Miharu ;

Ikeda, Kenji ;

Kumada, Hiromitsu .

HEPATOLOGY, 2009, 49 (03) :739-744

[8] No association between hepatitis C virus seropositivity and acute myocardial infarction [J].

Arcari, Christine M. ;

Nelson, Kenrad E. ;

Netski, Dale M. ;

Nieto, F. Javier ;

Gaydos, Charlotte A. .

CLINICAL INFECTIOUS DISEASES, 2006, 43 (06) :E53-E56

[9] The past incidence of hepatitis C virus infection: Implications for the future burden of chronic liver disease in the United States [J].

Armstrong, GL ;

Alter, MJ ;

McQuillan, GM ;

Margolis, HS .

HEPATOLOGY, 2000, 31 (03) :777-782

[10] Impaired IRS-1/PI3-kinase signaling in patients with HCV: A mechanism for increased prevalence of type 2 diabetes [J].

Aytug, S ;

Reich, D ;

Sapiro, LE ;

Bernstein, D ;

Begum, N .

HEPATOLOGY, 2003, 38 (06) :1384-1392

← 1 2 3 4 5 6 7 8 9 10 →