Morphological and Immunohistochemical Characterization of Spontaneous Mammary Gland Tumors in the Guinea Pig (Cavia porcellus)

被引：17

作者：

Suarez-Bonnet, A. ^{[1
]}

Martin de las Mulas, J. ^{[2
]}

Millan, M. Y. ^{[2
]}

Herraez, P. ^{[1
]}

Rodriguez, F. ^{[1
]}

Espinosa de los Monteros, A. ^{[1
]}

机构：

[1] Univ Las Palmas Gran Canaria, Sch Vet, Inst Anim Hlth, Unit Histol & Anim Pathol, Arucas 35413, Gran Canaria, Spain

[2] Univ Cordoba, Sch Vet, Dept Comparat Pathol, Cordoba, Spain

来源：

VETERINARY PATHOLOGY | 2010年 / 47卷 / 02期

关键词：

guinea pig; immunohistochemistry; mammary gland; progesterone receptor; estrogen receptor; spontaneous tumors; MONOCLONAL-ANTIBODIES; COORDINATE EXPRESSION; MUSCLE ACTIN; CARCINOMAS; CYTOKERATIN-20; COMPLEX; MARKER; FELINE; ALPHA; CELLS;

D O I：

10.1177/0300985809358426

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Ten spontaneous mammary gland tumors affecting guinea pigs (GP) were analyzed histologically and immunohistochemically. Histologically, 3 were benign (2 simple adenomas and I benign mixed tumor) and 7 were malignant (I simple solid carcinoma and 6 simple tubulopapillary carcinomas). Immunohistochemical data revealed the glandular immunoprofile of all the tumors and suggested their ductal origin on the basis of cytokeratin 20 expression. Interestingly, cytokeratin 7 was detected in basal/myoepithelial cells. Further, all tumors were positive for type a estrogen and progesterone receptors, suggesting a role for steroid hormones in the development of these neoplasias in GP. This article describes the morphological and immunohistochemical features of the normal mammary gland and spontaneous mammary gland tumors in GP.

引用

页码：298 / 305

页数：8

共 42 条

[21] KITCHEN DN, 1975, LAB ANIM SCI, V25, P92
[22] KOHLER H, 1979, SCHWEIZ ARCH TIERH, V121, P623
[23] Morphological and Immunohistochemical Studies of Spontaneous Mammary Tumours in Siberian Hamsters (Phodopus sungorus)
Kondo, H.
Onuma, M.
Shibuya, H.
Sato, T.
[J]. JOURNAL OF COMPARATIVE PATHOLOGY, 2009, 140 (2-3) : 127 - 131
[24] Martinez-Bauer EM, 2005, J HEPATOL, V42, P212
[25] Keratin 7 reactivity in endothelial cells: A potential pitfall in diagnostic immunohistochemistry
Miettinen, M
Fetsch, JF
[J]. APPLIED IMMUNOHISTOCHEMISTRY, 1997, 5 (04): : 229 - 233
[26] MIETTINEN M, 1995, MODERN PATHOL, V8, P384
[27] Misdorp W E., 1999, Histological Classification of Mammary Tumors of the Dog and the Cat, VVII
[28] MODIANO FJ, 2007, SMALL ANIMAL CLIN ON, P16
[29] THE HUMAN GENE ENCODING CYTOKERATIN-20 AND ITS EXPRESSION DURING FETAL DEVELOPMENT AND IN GASTROINTESTINAL CARCINOMAS
MOLL, R
ZIMBELMANN, R
GOLDSCHMIDT, MD
KEITH, M
LAUFER, J
KASPER, M
KOCH, PJ
FRANKE, WW
[J]. DIFFERENTIATION, 1993, 53 (02) : 75 - 93
[30] MOLL R, 1992, AM J PATHOL, V140, P427

← 1 2 3 4 5 →