Evolving therapeutic goals in Crohn's disease management

被引：12
作者：
Chateau, Thomas [1 ,2 ,3 ]
Peyrin-Biroulet, Laurent [2 ,3 ]
机构：
[1] Univ Grenoble Alpes, Univ Hosp Grenoble, Dept Hepatogastroenterol, Grenoble, France
[2] Univ Lorraine, Dept Gastroenterol, Univ Hosp Nancy, Vandoeuvre Les Nancy, France
[3] Univ Lorraine, Inserm NGERE, Univ Hosp Nancy, Vandoeuvre Les Nancy, France
来源：
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL | 2020年 / 8卷 / 02期
关键词：
Tight control; Crohn's disease; treat-to-target; INFLAMMATORY-BOWEL-DISEASE; C-REACTIVE PROTEIN; FECAL CALPROTECTIN; ENDOSCOPIC ACTIVITY; CLINICAL RELAPSE; DEEP REMISSION; ACTIVITY INDEX; INFLIXIMAB; AZATHIOPRINE; MULTICENTER;
D O I：
10.1177/2050640619887316
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
The main objectives in Crohn's disease are to avoid disease complications and preserve the patient's quality of life. Early disease control and close monitoring with specific targets to reach might be the only way to change the disease course. In two decades, we have moved from clinical response to full remission (clinical and endoscopic remission) requiring a tight monitoring of both symptoms and objective signs of inflammation. This review summarizes the concepts of tight control and treat-to-target and their potential for disease modification.
引用
收藏
页码：133 / 139
页数：7
相关论文
共 65 条
  • [1] Comparative Accuracy of Bowel Ultrasound Versus Magnetic Resonance Enterography in Combination With Colonoscopy in Assessing Crohn's Disease and Guiding Clinical Decision-making
    Allocca, Mariangela
    Fiorino, Gionata
    Bonifacio, Cristiana
    Furfaro, Federica
    Gilardi, Daniela
    Argollo, Marjorie
    Peyrin-Biroulet, Laurent
    Danese, Silvio
    [J]. JOURNAL OF CROHNS & COLITIS, 2018, 12 (11) : 1280 - 1287
  • [2] [Anonymous], 2019, CHANGING COURSE CROH
  • [3] [Anonymous], 2019, ENHANCED ALGORITHM C
  • [4] Mucosal Healing Predicts Sustained Clinical Remission in Patients With Early-Stage Crohn's Disease
    Baert, Filip
    Moortgat, Liesbeth
    Van Assche, Gert
    Caenepeel, Philip
    Vergauwe, Philippe
    De Vos, Martine
    Stokkers, Pieter
    Hommes, Daniel
    Rutgeerts, Paul
    Vermeire, Severine
    D'Haens, Geert
    [J]. GASTROENTEROLOGY, 2010, 138 (02) : 463 - 468
  • [5] Predictors of Crohn's disease
    Beaugerie, L
    Seksik, P
    Nion-Larmurier, I
    Gendre, JP
    Cosnes, J
    [J]. GASTROENTEROLOGY, 2006, 130 (03) : 650 - 656
  • [6] ECCO-ESCP Consensus on Surgery for Crohn's Disease
    Bemelman, Willem A.
    Warusavitarne, Janindra
    Sampietro, Gianluca M.
    Serclova, Zuzana
    Zmora, Oded
    Luglio, Gaetano
    van Overstraeten, Anthony de Buck
    Burke, John P.
    Buskens, Christianne J.
    Colombo, Francesco
    Dias, Jorge Amil
    Eliakim, Rami
    Elosua, Tomas
    Gecim, I. Ethem
    Kolacek, Sanja
    Kierkus, Jaroslaw
    Kolho, Kaija-Leena
    Lefevre, Jeremie H.
    Millan, Monica
    Panis, Yves
    Pinkney, Thomas
    Russell, Richard K.
    Shwaartz, Chaya
    Vaizey, Carolynne
    Yassin, Nuha
    D'Hoore, Andre
    [J]. JOURNAL OF CROHNS & COLITIS, 2018, 12 (01) : 1 - 16
  • [7] BEST WR, 1976, GASTROENTEROLOGY, V70, P439
  • [8] Patient Reported Outcome Measures (PROMs) in Inflammatory Bowel Disease: New Data
    Bojic, Daniela
    Bodger, Keith
    Travis, Simon
    [J]. JOURNAL OF CROHNS & COLITIS, 2017, 11 : S576 - S585
  • [9] Ultrasound for Assessing Disease Activity in IBD Patients: A Systematic Review of Activity Scores
    Bots, S.
    Nylund, K.
    Lowenberg, M.
    Gecse, K.
    Gilja, O. H.
    D'Haens, G.
    [J]. JOURNAL OF CROHNS & COLITIS, 2018, 12 (08) : 920 - 929
  • [10] Surgery for adult Crohn's disease: what is the actual risk?
    Bouguen, Guillaume
    Peyrin-Biroulet, Laurent
    [J]. GUT, 2011, 60 (09) : 1178 - 1181
1234567