Cell-Based Bio-Hybrid Delivery System for Disease Treatments

被引：8
作者：
Li, Chu-Xin [1 ,2 ]
Qi, Yong-Dan [1 ,2 ]
Feng, Jun [1 ,2 ]
Zhang, Xian-Zheng [1 ,2 ]
机构：
[1] Wuhan Univ, Minist Educ, Key Lab Biomed Polymers, Wuhan 430072, Peoples R China
[2] Wuhan Univ, Dept Chem, Wuhan 430072, Peoples R China
来源：
ADVANCED NANOBIOMED RESEARCH | 2021年 / 1卷 / 10期
基金：
中国国家自然科学基金;
关键词：
bio-hybrid; drug delivery; immune cells; live cells; synthetic materials; NEUTROPHIL EXTRACELLULAR TRAPS; ERYTHROCYTES-MEDIATED DELIVERY; STEM-CELLS; DEXAMETHASONE; 21-PHOSPHATE; DRUG-DELIVERY; ULCERATIVE-COLITIS; L-ASPARAGINASE; T-CELLS; CANCER; NANOPARTICLES;
D O I：
10.1002/anbr.202000052
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Live cells are implicated in diverse biological processes, including nutrient transport and removal of foreign substances. Their intelligent biofunctions with complex mechanisms cannot be replicated at all in man-made materials despite the significant advance in material design. Taking advantages of their biocompatibility and biotropic capability, various live cells have been developed as a kind of special carriers for the on-demand delivery of therapeutic and diagnostic agents in recent years. Furthermore, synthetic materials can be integrated with live cells to provide bio-hybrid systems that inherit advantages from both the synthetic particles and the natural cells. Herein, recent strategies and advances in cell-based bio-hybrid delivery systems for disease treatment are summarized. Challenges and opportunities in this field are also discussed.
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页数：15
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