Gold-catalyzed diastereoselective domino dearomatization/ipso-cyclization/aza-Michael sequence: a facile access to diverse fused azaspiro tetracyclic scaffolds

被引：68
作者：
He, Yi [1 ]
Li, Zhenghua [1 ,4 ]
Tian, Guilong [1 ]
Song, Liangliang [1 ]
Van Meervelt, Luc [2 ]
Van der Eycken, Erik V. [1 ,3 ]
机构：
[1] Katholieke Univ Leuven, Dept Chem, Lab Organ & Microwave Assisted Chem, Celestijnenlaan 200F, B-3001 Leuven, Belgium
[2] Katholieke Univ Leuven, Biomol Architecture, Dept Chem, Celestijnenlaan 200F, B-3001 Leuven, Belgium
[3] Peoples Friendship Univ Russia, RUDN Univ, 6 Miklukho Maklaya St, Moscow 117198, Russia
[4] RIKEN, Organometall Chem Lab, Wako, Saitama 3510198, Japan
来源：
CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 48期
关键词：
AMARYLLIDACEAE ALKALOID (+)-PLICAMINE; INTRAMOLECULAR HYDROARYLATION; MULTICOMPONENT REACTIONS; REGIOSELECTIVE SYNTHESIS; MOLECULAR COMPLEXITY; SUPPORTED REAGENTS; NATURAL-PRODUCTS; CASCADE REACTION; CONSTRUCTION; DERIVATIVES;
D O I：
10.1039/c7cc03152a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A facile and diversity-oriented access to complex tetracyclic benzo[e] pyrrolo[2,3-c] indole-2,4,7(5H)-triones through a post-Ugi gold(I)-catalyzed domino dearomatization/ipso-cyclization/aza-Michael sequence is elaborated. This process furnishes tetracyclic scaffolds in good yields from readily available precursors with unique diastereoselectivity.
引用
收藏
页码：6413 / 6416
页数：4
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