Gold-catalyzed diastereoselective domino dearomatization/ipso-cyclization/aza-Michael sequence: a facile access to diverse fused azaspiro tetracyclic scaffolds

被引：68

作者：

He, Yi ^{[1
]}

Li, Zhenghua ^{[1
,4
]}

Tian, Guilong ^{[1
]}

Song, Liangliang ^{[1
]}

Van Meervelt, Luc ^{[2
]}

Van der Eycken, Erik V. ^{[1
,3
]}

机构：

[1] Katholieke Univ Leuven, Dept Chem, Lab Organ & Microwave Assisted Chem, Celestijnenlaan 200F, B-3001 Leuven, Belgium

[2] Katholieke Univ Leuven, Biomol Architecture, Dept Chem, Celestijnenlaan 200F, B-3001 Leuven, Belgium

[3] Peoples Friendship Univ Russia, RUDN Univ, 6 Miklukho Maklaya St, Moscow 117198, Russia

[4] RIKEN, Organometall Chem Lab, Wako, Saitama 3510198, Japan

来源：

CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 48期

关键词：

AMARYLLIDACEAE ALKALOID (+)-PLICAMINE; INTRAMOLECULAR HYDROARYLATION; MULTICOMPONENT REACTIONS; REGIOSELECTIVE SYNTHESIS; MOLECULAR COMPLEXITY; SUPPORTED REAGENTS; NATURAL-PRODUCTS; CASCADE REACTION; CONSTRUCTION; DERIVATIVES;

D O I：

10.1039/c7cc03152a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A facile and diversity-oriented access to complex tetracyclic benzo[e] pyrrolo[2,3-c] indole-2,4,7(5H)-triones through a post-Ugi gold(I)-catalyzed domino dearomatization/ipso-cyclization/aza-Michael sequence is elaborated. This process furnishes tetracyclic scaffolds in good yields from readily available precursors with unique diastereoselectivity.

引用

页码：6413 / 6416

页数：4

共 73 条

[1] Gold-Catalyzed Dearomative Spirocyclization of Aryl Alkynoate Esters [J].