Ligand-Enabled Arylation of -C-H Bonds

被引：83
作者：
Li, Suhua [1 ]
Zhu, Ru-Yi [1 ]
Xiao, Kai-Jiong [1 ]
Yu, Jin-Quan [1 ]
机构：
[1] Scripps Res Inst, Dept Chem, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2016年 / 55卷 / 13期
关键词：
arylation; carboxylic acids; palladium; quinoline ligand; -C-H activation; ALPHA-AMINO-ACIDS; CATALYZED INTRAMOLECULAR AMINATION; UNACTIVATED C(SP(3))-H BONDS; LATE-STAGE DIVERSIFICATION; STEREOSELECTIVE-SYNTHESIS; C(SP(2))-H BONDS; ETHER SYNTHESIS; FUNCTIONALIZATION; ALKYLATION; SP(2);
D O I：
10.1002/anie.201512020
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Pd-II-catalyzed arylation of -C(sp(3))-H bonds of aliphatic acid-derived amides was developed by using quinoline-based ligands. Various -aryl--amino acids were prepared from natural amino acids using this method. The influence of ligand structure on reactivity was also systematically investigated.
引用
收藏
页码：4317 / 4321
页数：5
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