Ligand-Enabled Arylation of -C-H Bonds

被引：83

作者：

Li, Suhua ^{[1
]}

Zhu, Ru-Yi ^{[1
]}

Xiao, Kai-Jiong ^{[1
]}

Yu, Jin-Quan ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Chem, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2016年 / 55卷 / 13期

关键词：

arylation; carboxylic acids; palladium; quinoline ligand; -C-H activation; ALPHA-AMINO-ACIDS; CATALYZED INTRAMOLECULAR AMINATION; UNACTIVATED C(SP(3))-H BONDS; LATE-STAGE DIVERSIFICATION; STEREOSELECTIVE-SYNTHESIS; C(SP(2))-H BONDS; ETHER SYNTHESIS; FUNCTIONALIZATION; ALKYLATION; SP(2);

D O I：

10.1002/anie.201512020

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Pd-II-catalyzed arylation of -C(sp(3))-H bonds of aliphatic acid-derived amides was developed by using quinoline-based ligands. Various -aryl--amino acids were prepared from natural amino acids using this method. The influence of ligand structure on reactivity was also systematically investigated.

引用

页码：4317 / 4321

页数：5

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