New model of metalloantibiotic: synthesis, structure and biological activity of a zinc(ii) mononuclear complex carrying two enrofloxacin and sulfadiazine antibiotics

被引：20
作者：
Boughougal, Amina [1 ,2 ]
Cherchali, Fatma Zohra [1 ,3 ]
Messai, Amel [2 ]
Attik, Nina [1 ]
Decoret, Dominique [4 ]
Hologne, Maggy [5 ]
Sanglar, Corinne [5 ]
Pilet, Guillaume [1 ]
Tommasino, Jean Bernard [1 ]
Luneau, Dominique [1 ]
机构：
[1] Univ Claude Bernard Lyon 1, Univ Lyon, LMI, UMR 5615,CNRS, Ave 11 Novembre 1918, F-69622 Villeurbanne, France
[2] Abbes Laghrour Univ, Lab Ingn & Sci Mat Avances ISMA, Inst Sci & Technol, Khenchela 40000, Algeria
[3] USTHB, Fac Chim, LEPCMAE, Bab Ezzouar, Algeria
[4] Univ Lyon1, Univ Lyon, UFR Odontol, Lyon, France
[5] UCB Lyon 1, Univ Lyon, CNRS, Inst Sci Analyt,UMR 5280, 5 Rue Doua, F-69100 Villeurbanne, France
来源：
NEW JOURNAL OF CHEMISTRY | 2018年 / 42卷 / 18期
关键词：
ANTIMICROBIAL AGENTS; PK(A) VALUES; ELECTROPHORETIC BEHAVIOR; LIQUID-CHROMATOGRAPHY; COPPER(II) COMPLEXES; RETENTION BEHAVIOR; CRYSTAL-STRUCTURE; METAL-IONS; QUINOLONES; ANTIBACTERIAL;
D O I：
10.1039/c8nj01774c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new model of the Zn-based complex, [Zn(LH)(Erx)(ErxH)]ClO4 (sulfadiazine: LH and enrofloxacin ErxH), has been synthesised with two different, but complementary antibiotics (sulfonamide and quinolon) following an easy procedure. To evaluate the synergetic effect of this multicomponent molecule, the mononuclear complexes [Zn(L)(2)(H2O)(NH3)] and [Zn(Erx)(3)](-) which each include only one of the two antibiotics (sulfadiazine: LH or enrofloxacin ErxH) were synthesized. All three compounds were characterized, including crystal structure determination by single-crystal X-ray diffraction. For all of the complexes, enrofloxacin is coordinated to Zn(ii) by pyridinone and one oxygen atom of the carboxylate group in a monodente mode. The antibacterial activity, determined by the minimum inhibitory concentration on specific bacteria, has been studied on free ligands, on the corresponding mononuclear complexes and on our model.
引用
收藏
页码：15346 / 15352
页数：7
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