Phytonanotherapy for management of diabetes using green synthesis nanoparticles

被引:53
作者
Anand, K. [1 ]
Tiloke, C. [1 ,2 ]
Naidoo, Pragalathan [1 ]
Chuturgoon, A. A. [1 ]
机构
[1] Univ KwaZulu Natal, Sch Lab Med & Med Sci, Coll Hlth Sci, Discipline Med Biochem & Chem Pathol, Durban, South Africa
[2] Durban Univ Technol, Fac Appl Sci, Dept Chem, ZA-4001 Durban, South Africa
关键词
Gold nanoparticle; Antimicrobials; Diabetic; Cancer; Docking; Green synthesis; SILVER NANOPARTICLES; GOLD NANOPARTICLES; LEAF EXTRACT; PANCREATIC-CANCER; AQUEOUS EXTRACT; CASSIA-FISTULA; AG; MELLITUS; LEAVES; PLANTS;
D O I
10.1016/j.jphotobiol.2017.06.028
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The world has a rich diversity of indigenous medicinal plants. The World Health Organization (WHO) gives high priority to eco-friendly, non-hazardous and cost effective healthcare such as the use of medicinal plants to treat various illnesses, including Human immunodeficiency virus (HIV) infection and Acquired immune deficiency syndrome (AIDS), tuberculosis (TB), diabetes mellitus (DM), malaria, and cancer. In developing countries, a high proportion of the population tends to use complementary and alternative medicines (CAM) together with conventional prescription drugs. Globally, CAM has been used in both developed and developing countries. In China, 30-50% of medicinal use is based on traditional alternative medicine. In Africa, it is estimated that 80% of primary health care is CAM, whilst in the USA, about 158 million people us CAM. This increase is due to three main influences: improve their eminence of life, relieve symptoms and preclude long-term complications. Despite the advances and advantages of conventional pharmaceutical medication, these are associated with long-term side effects and pose risks of inefficacy for treatment of chronic diseases such as cancer and DM. The biosynthesis of metal nanoparticles (NPs) using medicinal plants has received considerable attention as a proper alternative to using hazardous chemical and physical synthetic techniques. Plants are being exploited for their unique metal tolerance and effective production of gold metal NPs. A single medicinal plant contains an orchestra of chemical elements (e.g. proteins, vitamins, enzymes, amino acids, polysaccharides and organic compounds) that are "environmentally benign, yet chemically complex" and therefore serve as ideal tools for enhanced medicinal applications. It is reported that phytocompounds such as terpenoids, polysaccharides, polyols and flavones take part in the bio-reduction, stabilization and bio-capping mechanisms to form stable gold and silver NPs. Also the inhibitory potential of plant compounds against diabetic targets followed by a study of enzyme inhibitor kinetics, ligand binding dynamics supported by in silico docking studies that reveal the mode of bioactive compounds and their inhibitory activities. The present review focuses on the potential anticancer, antidiabetic and antimicrobial activity of phyto-synthesized gold and silver NPs. In phytonanotherapy, synergistic features of plant and metal NPs are unique as they offer healing properties that may be the clinical bioequivalent to many synthetic drugs, with minimal side effects. This could provide alternative treatment for chronic diseases that is efficient to overcome the disadvantages of synthetic mono therapy and allows medicinal plant therapy to co-exist with current synthetic treatments. This creates a much needed paradigm shift for further clinical studies in non-communicable and communicable diseases.
引用
收藏
页码:626 / 639
页数:14
相关论文
共 109 条
[51]  
Maduna P., 2006, CME, V24, P574
[52]  
Malapermal V., 2015, Advanced Naterials Letters, V6, P1050, DOI DOI 10.5185/AMLETT.2015.5997
[53]  
Manam D., 2013, J Chem Pharm Res, V5, P1001
[54]  
McIntyre M., 2012, SYNERGY A KEY HERBAL
[55]   Use of a Lipid-Coated Mesoporous Silica Nanoparticle Platform for Synergistic Gemcitabine and Paclitaxel Delivery to Human Pancreatic Cancer in Mice [J].
Meng, Huan ;
Wang, Meiying ;
Liu, Huiyu ;
Liu, Xiangsheng ;
Situ, Allen ;
Wu, Bobby ;
Ji, Zhaoxia ;
Chang, Chong Hyun ;
Nel, Andre E. .
ACS NANO, 2015, 9 (04) :3540-3557
[56]   Herbal medicinals - Selected clinical considerations focusing on known or potential drug-herb interactions [J].
Miller, LG .
ARCHIVES OF INTERNAL MEDICINE, 1998, 158 (20) :2200-2211
[57]   Plant extract mediated synthesis of silver and gold nanoparticles and its antibacterial activity against clinically isolated pathogens [J].
MubarakAli, D. ;
Thajuddin, N. ;
Jeganathan, K. ;
Gunasekaran, M. .
COLLOIDS AND SURFACES B-BIOINTERFACES, 2011, 85 (02) :360-365
[58]  
Mukherjee PK, 2011, INDIAN J PHARM EDUC, V45, P210
[59]   The juice of fresh leaves of Catharanthus roseus Linn. reduces blood glucose in normal and alloxan diabetic rabbits [J].
Srinivas Nammi ;
Murthy K Boini ;
Srinivas D Lodagala ;
Ravindra Babu S Behara .
BMC Complementary and Alternative Medicine, 3 (1)
[60]   Molecular docking studies of (4Z, 12Z)-cyclopentadeca-4, 12-dienone from Grewia hirsuta with some targets related to type 2 diabetes [J].
Natarajan, Abirami ;
Sugumar, Shobana ;
Bitragunta, Sivakumar ;
Balasubramanyan, Natarajan .
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2015, 15