Pancreatic intraductal tubulopapillary neoplasm with associated invasive cancer successfully treated by total pancreatectomy: A case report

被引：11

作者：

Fujimoto, Yuji ^{[1
]}

Tomimaru, Yoshito ^{[1
]}

Tamura, Hiromi ^{[2
]}

Noguchi, Kozo ^{[1
]}

Nagasei, Hirotsugu ^{[1
]}

Hamabe, Atsushi ^{[1
]}

Hirota, Masashi ^{[1
]}

Oshima, Kazuteru ^{[1
]}

Tanida, Tsuicasa ^{[1
]}

Kawase, Tomono ^{[1
]}

Morita, Shunji ^{[1
]}

Imamura, Hiroshi ^{[1
]}

Iwazawa, Takashi ^{[1
]}

Akagi, Kenzo ^{[1
]}

Yamamoto, Masashi ^{[3
]}

Nishida, Tsutomu ^{[3
]}

Adachi, Shiro ^{[2
]}

Dono, Keizo ^{[1
]}

机构：

[1] Toyonaka City Hosp, Dept Surg, 4-14-1 Shibahara, Toyonaka, Osaka 5608565, Japan

[2] Toyonaka City Hosp, Dept Pathol, Toyonaka, Osaka 5608565, Japan

[3] Toyonaka City Hosp, Dept Gastroenterol, Toyonaka, Osaka 5608565, Japan

来源：

ONCOLOGY LETTERS | 2017年 / 14卷 / 01期

关键词：

intraductal tubulopapillary neoplasm; intraductal neoplasm; pancreatic cancer; pancreas; FINE-NEEDLE-ASPIRATION; FEATURES;

D O I：

10.3892/ol.2017.6130

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A 74-year-old male was admitted to Departments of Surgery, Toyonaka Municipal Hospital (Osaka, Japan) for treatment of a pancreatic tumor. Contrast enhanced computed tomography (CT) revealed a mass with small cystic lesions in the pancreatic head and body. Fluorodeoxyglucose-positron emission tomography/CT revealed an abnormal uptake of fluorodeoxyglucose, corresponding to the mass lesions. Upper gastrointestinal endoscopy revealed rough mucosa near the opening of the accessory pancreatic duct, and the mucosa biopsy exhibited adenocarcinoma with no mucin observed. The preoperative diagnosis was pancreatic intraductal tubulo-papillary neoplasm (ITPN) with cancerous lesions, and a total pancreatectomy with splenectomy was performed. The resected tissue specimen revealed a solid tumor occupying the entire pancreas with intraductal growth into the main-pancreatic duct. Histological examination revealed high-grade dysplastic cells in a tubulopapillary growth pattern without overt mucin production beyond the pancreatic duct. Immunohistochemical staining analysis of the tumor was positive for cytokeratin (CK)7, CK19 and mucin (MUC)1, and negative for MUC2, MUC5AC, MUC6 and caudal type homeobox 2. The tumor was finally diagnosed as pancreatic ITPN with associated invasive cancer. The patient remains well without evident recurrence nine months post-surgery. ITPN is a rare type of epithelial neoplasm of the pancreas, and is characterized by intraductal tubulo-papillary growth, ductal differentiation, limited intracellular mucin production, and cellular dysplasia. The present case report may contribute to improved understanding of how to effectively treat patients with ITPN.

引用

页码：153 / 158

页数：6

共 20 条

[1]

Adsay NV., 2010, WHO CLASSIFICATION T, P304

[2] Case report: intraductal tubulopapillary neoplasm of the pancreas with unique clear cell phenotype [J].

Ahls, Maria Gabriele ;

Niedergethmann, Marco ;

Dinter, Dietmar ;

Sauer, Christian ;

Luettges, Jutta ;

Post, Stefan ;

Marx, Alexander ;

Gaiser, Timo .

DIAGNOSTIC PATHOLOGY, 2014, 9

[3]

[Anonymous], BMJ CASE REP

[4] Clinicopathological features and surgical outcomes of intraductal tubulopapillary neoplasm of the pancreas: a systematic review [J].

Date, Keiichi ;

Okabayashi, Takehiro ;

Shima, Yasuo ;

Iwata, Jun ;

Sumiyoshi, Tatsuaki ;

Kozuki, Akihito ;

Morita, Sojiro ;

Hata, Yasuhiro ;

Noda, Yoshihiro ;

Nishioka, Akihito ;

Matsumoto, Manabu .

LANGENBECKS ARCHIVES OF SURGERY, 2016, 401 (04) :439-447

[5] Is intraductal tubulopapillary neoplasia a new entity in the spectrum of familial pancreatic cancer syndrome? [J].

Del Chiaro, Marco ;

Mucelli, Raffaella Pozzi ;

Blomberg, John ;

Segersvard, Ralf ;

Verbeke, Caroline .

FAMILIAL CANCER, 2014, 13 (02) :227-229

[6] Intraductal tubulopapillary neoplasm with expansile invasive carcinoma of the pancreas diagnosed by endoscopic ultrasonography-guided fine needle aspiration: A case report [J].

Furuhata, Ayako ;

Minamiguchi, Sachiko ;

Mikami, Yoshiki ;

Kodama, Yuzo ;

Sumiyoshi, Shinji ;

Adachi, Souichi ;

Haga, Hironori .

DIAGNOSTIC CYTOPATHOLOGY, 2014, 42 (04) :314-320

[7] Intraductal tubulopapillary neoplasm of the pancreas on fine needle aspiration: Case Report with Differential Diagnosis [J].

Guan, Hui ;

Gurda, Grzegorz ;

Lennon, Anne Marie ;

Hruban, Ralph H. ;

Erozan, Yener S. .

DIAGNOSTIC CYTOPATHOLOGY, 2014, 42 (02) :156-160

[8] Intraductal tubulopapillary neoplasm of pancreas with stromal osseous and cartilaginous metaplasia; a case report [J].

Jokoji, Ryu ;

Tsuji, Hiromi ;

Tsujimoto, Masahiko ;

Shinno, Naoki ;

Tori, Masayuki .

PATHOLOGY INTERNATIONAL, 2012, 62 (05) :339-343

[9] Intraductal Tubulopapillary Neoplasms of the Pancreas: Case Report and Review of the Literature [J].

Kasugai, Hisashi ;

Tajiri, Takuma ;

Takehara, Yusuke ;

Mukai, Shumpei ;

Tanaka, Jun-ichi ;

Kudoi, Shin-ei .

JOURNAL OF NIPPON MEDICAL SCHOOL, 2013, 80 (03) :224-229

[10] A Resected Case of Intraductal Tubulopapillary Neoplasm of the Pancreas: Report of a Case [J].

Kitaguchi, Kazuhiko ;

Kato, Yuichiro ;

Kojima, Motohiro ;

Okubo, Satoshi ;

Takahashi, Daigoro ;

Okada, Rei ;

Nakayama, Yusuke ;

Nishida, Yasunori ;

Gotohda, Naoto ;

Takahashi, Shinichiro ;

Konishi, Masaru .

INTERNATIONAL SURGERY, 2015, 100 (02) :281-286

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