Double-stranded nucleic acids in liquid-crystalline dispersions as building blocks for cross-linked supramolecular structures

被引：7

作者：

Yevdokimov, YM

Salyanov, VI

Mchedlischvili, BV

Bykov, VA

Belyaev, AV

Saunin, SA

Spener, F

Palumbo, M

机构：

[1] Russian Acad Sci, VA Engelhardt Mol Biol Inst, Moscow 117984, Russia

[2] Russian Acad Sci, Inst Crystallog, Moscow 11733, Russia

[3] NT MTD Co, Zelenograd Res Inst Phys Problems, Moscow 103460, Russia

[4] Univ Munster, Inst Biochem, D-48149 Munster, Germany

[5] Univ Padua, Dept Pharmaceut Sci, I-35131 Padua, Italy

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2000年 / 19卷 / 08期

关键词：

D O I：

10.1080/15257770008033057

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Double-stranded DNA fixed in a cholesteric liquid-crystalline dispersion was used for generating an ordered supramolecular structure in the presence of anthracycline and copper (II) ions. The structure is stable in a water-salt solution and does not require poly(ethyleneglycol). The ordered network can be immobilized on the surface of a polymeric film, and may collapse in the presence of biologically and pharmacologically relevant compounds. Accordingly, the DNA-based liquid-crystalline network represents the basis to obtain novel highly sensitive biosensing units.

引用

页码：1355 / 1364

页数：10

共 13 条

[1]

BASOLO F, 1971, MECH INORGANIC REACT, P70

[2] Comparison of calculated and observed CD spectra of liquid crystalline dispersions formed from double-stranded DNA and from DNA complexes with coloured compounds [J].