Oncohistone Mutations in Diffuse Intrinsic Pontine Glioma

被引：17
|
作者：
Zhang, Xu [1 ,2 ,3 ]
Zhang, Zhiguo [1 ,2 ,3 ]
机构：
[1] Columbia Univ, Irving Med Ctr, Inst Canc Genet, New York, NY 10032 USA
[2] Columbia Univ, Irving Med Ctr, Dept Pediat, New York, NY 10032 USA
[3] Columbia Univ, Irving Med Ctr, Dept Genet & Dev, New York, NY 10032 USA
来源：
TRENDS IN CANCER | 2019年 / 5卷 / 12期
关键词：
PEDIATRIC HIGH-GRADE; HISTONE METHYLTRANSFERASE ACTIVITY; POTENTIAL THERAPEUTIC TARGET; H3.3K27M MUTATION; DRIVER MUTATIONS; POLYCOMB; METHYLATION; DNA; INHIBITION; COMPLEX;
D O I：
10.1016/j.trecan.2019.10.009
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Diffuse intrinsic pontine glioma (DIPG) is a lethal pediatric tumor with no currently available treatment options. More than 60-70% DIPGtumors harbor heterozygous mutations at genes encoding histone H3 proteins that replace lysine 27 with methionine (K27M). In this review, we discuss how K27M mutation reprograms the cancer epigenome to lead to tumorigenesis, and highlight potential drug targets and therapeutic agents for DIPG.
引用
收藏
页码：799 / 808
页数：10
相关论文
共 50 条
  • [1] INSIGHTS INTO TUMORIGENESIS OF DIFFUSE INTRINSIC PONTINE GLIOMA-ONCOHISTONE AND SIGNALING
    Sun, Ye
    Yan, Kun
    Wang, Dan
    Zhou, Wei
    Wang, Yi
    Xu, Cheng
    Han, Yujie
    Tang, Yujie
    Zhang, Liwei
    Xi, Qiaoran
    NEURO-ONCOLOGY, 2023, 25
  • [2] Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma
    Hamid Nikbakht
    Eshini Panditharatna
    Leonie G. Mikael
    Rui Li
    Tenzin Gayden
    Matthew Osmond
    Cheng-Ying Ho
    Madhuri Kambhampati
    Eugene I. Hwang
    Damien Faury
    Alan Siu
    Simon Papillon-Cavanagh
    Denise Bechet
    Keith L. Ligon
    Benjamin Ellezam
    Wendy J. Ingram
    Caedyn Stinson
    Andrew S. Moore
    Katherine E. Warren
    Jason Karamchandani
    Roger J. Packer
    Nada Jabado
    Jacek Majewski
    Javad Nazarian
    Nature Communications, 7
  • [3] SPATIAL AND TEMPORAL HOMOGENEITY OF DRIVER MUTATIONS IN DIFFUSE INTRINSIC PONTINE GLIOMA
    Panditharatna, Eshini
    Nikbakht, Hamid
    Mikael, Leonie
    Li, Rui
    Gayden, Tenzin
    Osmand, Matthew
    Ho, Cheng-Ying
    Kambhampati, Madhuri
    Hwang, Eugene I.
    Faury, Damien
    Siu, Alan
    Papillon-Cavanagh, Simon
    Bechet, Denise
    Ligon, Keith L.
    Ellezam, Benjamin
    Ingram, Wendy J.
    Stinson, Caedyn
    Moore, Andrew S.
    Warren, Katherine E.
    Karamchandani, Jason
    Packer, Roger J.
    Jabado, Nada
    Majewski, Jacek
    Nazarian, Javad
    NEURO-ONCOLOGY, 2016, 18 : 66 - 66
  • [4] Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma
    Nikbakht, Hamid
    Panditharatna, Eshini
    Mikael, Leonie G.
    Li, Rui
    Gayden, Tenzin
    Osmond, Matthew
    Ho, Cheng-Ying
    Kambhampati, Madhuri
    Hwang, Eugene I.
    Faury, Damien
    Siu, Alan
    Papillon-Cavanagh, Simon
    Bechet, Denise
    Ligon, Keith L.
    Ellezam, Benjamin
    Ingram, Wendy J.
    Stinson, Caedyn
    Moore, Andrew S.
    Warren, Katherine E.
    Karamchandani, Jason
    Packer, Roger J.
    Jabado, Nada
    Majewski, Jacek
    Nazarian, Javad
    NATURE COMMUNICATIONS, 2016, 7
  • [5] Diffuse intrinsic pontine glioma: a reassessment
    Robison, Nathan J.
    Kieran, Mark W.
    JOURNAL OF NEURO-ONCOLOGY, 2014, 119 (01) : 7 - 15
  • [6] Diffuse intrinsic pontine glioma: a reassessment
    Nathan J. Robison
    Mark W. Kieran
    Journal of Neuro-Oncology, 2014, 119 : 7 - 15
  • [7] Critical oncogenic mutations in newly diagnosed pediatric diffuse intrinsic pontine glioma
    Grill, Jacques
    Puget, Stephanie
    Andreiuolo, Felipe
    Philippe, Cathy
    MacConaill, Laura
    Kieran, Mark W.
    PEDIATRIC BLOOD & CANCER, 2012, 58 (04) : 489 - 491
  • [8] Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma
    Kathryn R Taylor
    Alan Mackay
    Nathalène Truffaux
    Yaron S Butterfield
    Olena Morozova
    Cathy Philippe
    David Castel
    Catherine S Grasso
    Maria Vinci
    Diana Carvalho
    Angel M Carcaboso
    Carmen de Torres
    Ofelia Cruz
    Jaume Mora
    Natacha Entz-Werle
    Wendy J Ingram
    Michelle Monje
    Darren Hargrave
    Alex N Bullock
    Stéphanie Puget
    Stephen Yip
    Chris Jones
    Jacques Grill
    Nature Genetics, 2014, 46 : 457 - 461
  • [9] Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma
    Taylor, Kathryn R.
    Mackay, Alan
    Truffaux, Nathalene
    Butterfield, Yaron S.
    Morozova, Olena
    Philippe, Cathy
    Castel, David
    Grasso, Catherine S.
    Vinci, Maria
    Carvalho, Diana
    Carcaboso, Angel M.
    de Torres, Carmen
    Cruz, Ofelia
    Mora, Jaume
    Entz-Werle, Natacha
    Ingram, Wendy J.
    Monje, Michelle
    Hargrave, Darren
    Bullock, Alex N.
    Puget, Stephanie
    Yip, Stephen
    Jones, Chris
    Grill, Jacques
    NATURE GENETICS, 2014, 46 (05) : 457 - 461
  • [10] THE ROLE OF ACVR1 MUTATIONS IN DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)
    Taylor, Katy
    Mackay, Alan
    Vinci, Mara
    Popov, Sergey
    Ingram, Wendy
    Entz-Werle, Natacha
    Monje, Michelle
    Olaciregui, Nagore
    Mora, Jaume
    Carcaboso, Angel
    Bullock, Alex
    Jones, Chris
    NEURO-ONCOLOGY, 2014, 16 : 49 - 49
12345