A new N-methoxyl-carbonyl benzylisoquinoline from Litsea cubeba

被引：4
|
作者：
Tang, Bin [1 ]
Tu, Hua [1 ]
Long, Han-An [1 ]
Du, Jun [1 ]
Guo, Jian-Min [1 ]
Liu, Hong-Jin [2 ]
Hu, Xin [3 ]
Yang, Li [4 ]
Du, Xi [1 ]
机构：
[1] Southwest Med Univ, Basic Med Coll, Luzhou 646100, Peoples R China
[2] Southwest Med Univ, Affiliated Hosp 1, Luzhou 646000, Peoples R China
[3] Southwest Med Univ, Affiliated Hosp 2, Luzhou 646000, Peoples R China
[4] Yibin Univ, Coll Chem & Chem Engn, Yibin 644007, Peoples R China
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2017年 / 19卷 / 09期
关键词：
Lauraceae; Litsea cubeba; benzylisoquinoline; X-ray diffraction; cytotoxicity; ISOQUINOLINE ALKALOIDS;
D O I：
10.1080/10286020.2016.1275582
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A new benzylisoquinoline alkaloid (center dot)-N-methoxycarbonyl-norjuziphine (1) was isolated from Litsea cubeba. Its structure was identified by extensively spectroscopic techniques and confirmed by the single-crystal X-ray diffraction analysis. Compound 1 showed cytotoxicity against HL-60 and MCF-7 cells, with IC50 values of 18.1 and 15.0M, respectively, comparable to 3.1 and 17.5M of the cisplatin (positive control).
引用
收藏
页码：941 / 945
页数：5
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