A new N-methoxyl-carbonyl benzylisoquinoline from Litsea cubeba

被引：4
|
作者：
Tang, Bin [1 ]
Tu, Hua [1 ]
Long, Han-An [1 ]
Du, Jun [1 ]
Guo, Jian-Min [1 ]
Liu, Hong-Jin [2 ]
Hu, Xin [3 ]
Yang, Li [4 ]
Du, Xi [1 ]
机构：
[1] Southwest Med Univ, Basic Med Coll, Luzhou 646100, Peoples R China
[2] Southwest Med Univ, Affiliated Hosp 1, Luzhou 646000, Peoples R China
[3] Southwest Med Univ, Affiliated Hosp 2, Luzhou 646000, Peoples R China
[4] Yibin Univ, Coll Chem & Chem Engn, Yibin 644007, Peoples R China
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2017年 / 19卷 / 09期
关键词：
Lauraceae; Litsea cubeba; benzylisoquinoline; X-ray diffraction; cytotoxicity; ISOQUINOLINE ALKALOIDS;
D O I：
10.1080/10286020.2016.1275582
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A new benzylisoquinoline alkaloid (center dot)-N-methoxycarbonyl-norjuziphine (1) was isolated from Litsea cubeba. Its structure was identified by extensively spectroscopic techniques and confirmed by the single-crystal X-ray diffraction analysis. Compound 1 showed cytotoxicity against HL-60 and MCF-7 cells, with IC50 values of 18.1 and 15.0M, respectively, comparable to 3.1 and 17.5M of the cisplatin (positive control).
引用
收藏
页码：941 / 945
页数：5
相关论文
共 50 条
  • [1] Two New Isoquinoline Alkaloids from Litsea cubeba
    Feng, Tao
    Zhang, Rong-Ting
    Tan, Qin-Gang
    Zhang, Xiang-Yun
    Liu, Ya-Ping
    Cai, Xiang-Hai
    Luo, Xiao-Dong
    ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, 2009, 64 (07): : 871 - 874
  • [2] Two new terpenoid ester glycosides from the twigs of Litsea cubeba
    Wang, Ling-Yan
    Tian, Ye
    Qu, Yu-Hong
    Wu, Yu-Zhuo
    Li, Yan-Cheng
    Li, Rui
    Lin, Peng-Cheng
    Shang, Xiao-Ya
    Lin, Sheng
    JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2018, 20 (12) : 1129 - 1136
  • [3] Lignans from the Twigs of Litsea cubeba and Their Bioactivities
    Li, Xiuting
    Xia, Huan
    Wang, Lingyan
    Xia, Guiyang
    Qu, Yuhong
    Shang, Xiaoya
    Lin, Sheng
    MOLECULES, 2019, 24 (02)
  • [4] Bioactive sesquineolignans from the twigs of Litsea cubeba
    Xia Huan
    Xia Gui-Yang
    Wang Ling-Yan
    Wang Min
    Wang Ya-Nan
    Lin Peng-Chene
    Lin Sheng
    CHINESE JOURNAL OF NATURAL MEDICINES, 2021, 19 (10) : 796 - 800
  • [5] Two dibenzopyrrocoline alkaloids from Litsea cubeba
    Lee, SS
    Chen, CK
    Huang, FM
    Chen, CH
    JOURNAL OF NATURAL PRODUCTS, 1996, 59 (01): : 80 - 82
  • [6] Bioactive Glycosides from the Twigs of Litsea cubeba
    Wang, Ling-Yan
    Chen, Ming-Hua
    Wu, Jiang
    Sun, Hua
    Liu, Wei
    Qu, Yu-Hong
    Li, Yan-Cheng
    Wu, Yu-Zhuo
    Li, Rui
    Zhang, Dan
    Wang, Su-Juan
    Lin, Sheng
    JOURNAL OF NATURAL PRODUCTS, 2017, 80 (06): : 1808 - 1818
  • [7] Bioactive sesquineolignans from the twigs of Litsea cubeba
    XIA Huan
    XIA Gui-Yang
    WANG Ling-Yan
    WANG Min
    WANG Ya-Nan
    LIN Peng-Cheng
    LIN Sheng
    Chinese Journal of Natural Medicines, 2021, 19 (10) : 796 - 800
  • [8] Chemical constituents from the roots and stems of Litsea cubeba
    Guo, Qiang
    Bai, Rui-Feng
    Su, Guo-Zhu
    Zhu, Zhi-Xiang
    Zeng, Ke-Wu
    Tu, Peng-Fei
    Chai, Xing-Yun
    JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2016, 18 (01) : 51 - 58
  • [9] ADDITIONAL ISOQUINOLINE ALKALOIDS FROM LITSEA-CUBEBA
    LEE, SS
    CHEN, CK
    CHEN, IS
    LIU, KCS
    JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 1992, 39 (05) : 453 - 455
  • [10] Antimicrobially Active Isoquinoline Alkaloids from Litsea cubeba
    Feng, Tao
    Xu, Yan
    Cai, Xiang-Hai
    Du, Zhi-Zhi
    Luo, Xiao-Dong
    PLANTA MEDICA, 2009, 75 (01) : 76 - 79
12345