Macrophage MicroRNAs as Therapeutic Targets for Atherosclerosis, Metabolic Syndrome, and Cancer

被引：25
|
作者：
Wei, Yuanyuan [1 ,2 ]
Zhu, Mengyu [1 ]
Schober, Andreas [1 ,2 ]
机构：
[1] Ludwig Maximilians Univ Munchen, Inst Cardiovasc Prevent, Expt Vasc Med, D-80336 Munich, Germany
[2] German Ctr Cardiovasc Res DZHK, Partner Site Munich Heart Alliance, D-80802 Munich, Germany
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 06期
关键词：
immune disorders; microRNA; macrophage; lipid metabolism; chronic inflammation; TUMOR-ASSOCIATED MACROPHAGES; NF-KAPPA-B; ADIPOSE-TISSUE MACROPHAGES; COLONY-STIMULATING FACTOR; NITRIC-OXIDE SYNTHASE; PROMOTES ATHEROSCLEROSIS; ALTERNATIVE ACTIVATION; CHOLESTEROL EFFLUX; KETONE-BODIES; IMMUNE CELLS;
D O I：
10.3390/ijms19061756
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Macrophages play a crucial role in the innate immune system and contribute to a broad spectrum of pathologies in chronic inflammatory diseases. MicroRNAs (miRNAs) have been demonstrated to play important roles in macrophage functions by regulating macrophage polarization, lipid metabolism and so on. Thus, miRNAs represent promising diagnostic and therapeutic targets in immune disorders. In this review, we will summarize the role of miRNAs in atherosclerosis, metabolic syndrome, and cancer by modulating macrophage phenotypes, which has been supported by in vivo evidence.
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页数：20
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