Application of Gold Nanoparticle to Plasmonic Biosensors

被引：134

作者：

Lee, Jin-Ho ^{[1
,2
]}

Cho, Hyeon-Yeol ^{[1
,2
]}

Choi, Hye Kyu ^{[1
]}

Lee, Ji-Young ^{[1
]}

Choi, Jeong-Woo ^{[1
]}

机构：

[1] Sogang Univ, Dept Chem & Biomol Engn, 35 Baekbeom Ro, Seoul 04107, South Korea

[2] Rutgers State Univ, Dept Chem & Chem Biol, Piscataway, NJ 08854 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 07期

基金：

新加坡国家研究基金会;

关键词：

gold nanoparticles; plasmon; biosensor; molecular diagnosis; ENHANCED RAMAN-SCATTERING; LABEL-FREE DETECTION; COLORIMETRIC DETECTION; BIOMEDICAL APPLICATIONS; ULTRASENSITIVE DETECTION; METAL NANOPARTICLES; STEM-CELLS; DNA; FLUORESCENCE; SPECTROSCOPY;

D O I：

10.3390/ijms19072021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gold nanoparticles (GNPs) have been widely utilized to develop various biosensors for molecular diagnosis, as they can be easily functionalized and exhibit unique optical properties explained by plasmonic effects. These unique optical properties of GNPs allow the expression of an intense color under light that can be tuned by altering their size, shape, composition, and coupling with other plasmonic nanoparticles. Additionally, they can also enhance other optical signals, such as fluorescence and Raman scattering, making them suitable for biosensor development. In this review, we provide a detailed discussion of the currently developed biosensors based on the aforementioned unique optical features of GNPs. Mainly, we focus on four different plasmonic biosensing methods, including localized surface plasmon resonance (LSPR), surface-enhanced Raman spectroscopy (SERS), fluorescence enhancement, and quenching caused by plasmon and colorimetry changes based on the coupling of GNPs. We believe that the topics discussed here are useful and able to provide a guideline in the development of novel GNP-based biosensors in the future.

引用

页数：14

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