An in vivo confocal microscopy study of corneal changes in patients with systemic sclerosis

被引:4
作者
Szalai, Eszter [1 ,2 ]
Szucs, Gabriella [3 ]
Szamosi, Szilvia [3 ]
Aszalos, Zsuzsa [4 ]
Afra, Ildiko [2 ]
Kemeny-Beke, Adam [2 ]
机构
[1] Univ Pecs, Dept Ophthalmol, Rakoczi U 2, H-7623 Pecs, Hungary
[2] Univ Debrecen, Fac Med, Dept Ophthalmol, Nagyerdei Krt 98, H-4032 Debrecen, Hungary
[3] Univ Debrecen, Fac Med, Inst Med, Dept Rheumatol, Nagyerdei Krt 98, H-4032 Debrecen, Hungary
[4] Univ Debrecen, Fac Med, Inst Med, Dept Immunol, Moricz Zsigmond Krt 22, H-4032 Debrecen, Hungary
关键词
DIABETIC PERIPHERAL NEUROPATHY; CLASSIFICATION CRITERIA; SJOGRENS-SYNDROME; NERVES; HEALTH; INVOLVEMENT; MORPHOLOGY; DIAGNOSIS; EYE;
D O I
10.1038/s41598-021-90594-9
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
To investigate corneal microstructure of systemic sclerosis (SSc) patients using in vivo confocal microscopy (IVCM). 33 patients with SSc and 30 age-matched healthy subjects were recruited. All participants underwent comprehensive ophthalmic examination including IVCM (Heidelberg Retina Tomograph III, Heidelberg Engineering GmbH, Heidelberg, Germany) and ocular surface evaluation. Subbasal nerve plexus morphology was investigated using automated software analysis (ACCMetrics V3; University of Manchester, Manchester, UK). Keratocyte cell densities in the anterior stroma were significantly lower in patients with SSc compared to controls (P<0.0001). In 7 SSc patients no keratocyte nuclei were identified in the anterior stroma and in most patients scattered hyperreflective punctate material were observed in the anterior stroma. Significantly lower subbasal nerve fiber parameters were found in patients with SSc compared to healthy subjects (P<0.05). There were no significant correlations between the duration of SSc and any of the corneal cell density values. Tear break-up time values (4.82 +/- 3.15 s) and Ocular Surface Disease Index scores (33.27 +/- 30.11) were abnormal, Schirmer values (6.78 +/- 5.82 mm) were borderline in SSc patients. In SSc, corneal morphological changes and accumulation of punctate material in the stroma was detected with confocal microscopy. Severe ocular surface disease was observed in SSc patients with significant impairment in subbasal nerve plexus morphology resembling peripheral neuropathy.
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页数:7
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